1-[5-benzyloxy-7-[(E)-N-methoxy-C-methyl-carbonimidoyl]-1,3-benzothiazol-2-yl]-3-ethyl-urea

Base Information

Chemical Name:1-[5-benzyloxy-7-[(E)-N-methoxy-C-methyl-carbonimidoyl]-1,3-benzothiazol-2-yl]-3-ethyl-urea
CAS No.:1372548-67-8
Molecular Formula:C₂₀H₂₂N₄O₃S
Molecular Weight:398.486
Hs Code.:

Synonyms:1-[5-benzyloxy-7-[(E)-N-methoxy-C-methyl-carbonimidoyl]-1,3-benzothiazol-2-yl]-3-ethyl-urea

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Chemical Property of 1-[5-benzyloxy-7-[(E)-N-methoxy-C-methyl-carbonimidoyl]-1,3-benzothiazol-2-yl]-3-ethyl-urea

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Technology Process of 1-[5-benzyloxy-7-[(E)-N-methoxy-C-methyl-carbonimidoyl]-1,3-benzothiazol-2-yl]-3-ethyl-urea

There total 12 articles about 1-[5-benzyloxy-7-[(E)-N-methoxy-C-methyl-carbonimidoyl]-1,3-benzothiazol-2-yl]-3-ethyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1372548-66-7
1-(7-acetyl-5-benzyloxy-1,3-benzothiazol-2-yl)-3-ethyl-urea

: 593-56-6
N-methoxylamine hydrochloride

: 1372548-67-8
1-[5-benzyloxy-7-[(E)-N-methoxy-C-methyl-carbonimidoyl]-1,3-benzothiazol-2-yl]-3-ethyl-urea

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield:

: 121-88-0
5-Nitro-2-aminophenol

: 1372548-67-8
1-[5-benzyloxy-7-[(E)-N-methoxy-C-methyl-carbonimidoyl]-1,3-benzothiazol-2-yl]-3-ethyl-urea

Guidance literature:: Multi-step reaction with 11 steps

1.1: bromine / acetonitrile / 1 h / 30 - 35 °C / Industry scale

2.1: sulfuric acid; sodium nitrite / ethanol / -10 - 55 °C

3.1: potassium carbonate / acetone / 3 h / Reflux; Industry scale

4.1: tin(II) chloride dihdyrate / tetrahydrofuran / 3 h / Reflux; Industry scale

4.2: 0 - 5 °C

5.1: acetone / 0.75 h / 20 °C

6.1: water; sodium hydroxide / tetrahydrofuran / 69 - 70 °C

7.1: bromine / acetonitrile / 1.5 h / 0 - 20 °C

8.1: 1,4-dioxane / 80 - 85 °C

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

10.1: hydrogenchloride; water / tetrahydrofuran / 4 h / 20 °C

11.1: N,N-dimethyl-formamide / 2 h / 60 °C

With hydrogenchloride; tin(II) chloride dihdyrate; sulfuric acid; water; bromine; potassium carbonate; sodium hydroxide; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 116632-23-6
3-bromo-5-nitro-phenol

: 1372548-67-8
1-[5-benzyloxy-7-[(E)-N-methoxy-C-methyl-carbonimidoyl]-1,3-benzothiazol-2-yl]-3-ethyl-urea

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / acetone / 3 h / Reflux; Industry scale

2.1: tin(II) chloride dihdyrate / tetrahydrofuran / 3 h / Reflux; Industry scale

2.2: 0 - 5 °C

3.1: acetone / 0.75 h / 20 °C

4.1: water; sodium hydroxide / tetrahydrofuran / 69 - 70 °C

5.1: bromine / acetonitrile / 1.5 h / 0 - 20 °C

6.1: 1,4-dioxane / 80 - 85 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

8.1: hydrogenchloride; water / tetrahydrofuran / 4 h / 20 °C

9.1: N,N-dimethyl-formamide / 2 h / 60 °C

With hydrogenchloride; tin(II) chloride dihdyrate; water; bromine; potassium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetone; acetonitrile;