6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclohexyl)pyrido[3,2-h]quinazolin-4(3H)-one

Base Information

Chemical Name:6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclohexyl)pyrido[3,2-h]quinazolin-4(3H)-one
CAS No.:1312166-07-6
Molecular Formula:C₂₃H₂₁ClN₄O₂
Molecular Weight:420.898
Hs Code.:

Synonyms:6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclohexyl)pyrido[3,2-h]quinazolin-4(3H)-one

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Chemical Property of 6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclohexyl)pyrido[3,2-h]quinazolin-4(3H)-one

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Technology Process of 6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclohexyl)pyrido[3,2-h]quinazolin-4(3H)-one

There total 11 articles about 6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclohexyl)pyrido[3,2-h]quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-15-7,931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5
(1S,2S)-trans-2-aminocyclohexanol

: 1312166-07-6
6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclohexyl)pyrido[3,2-h]quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

2: N,N-dimethyl-formamide / 16 h / 140 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 8-amino-5-((6-chloropyridin-3-yl)methyl)-N-((1S,2S)-2-hydroxycyclohexyl)quinoline-7-carboxamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1312166-07-6
6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclohexyl)pyrido[3,2-h]quinazolin-4(3H)-one

Guidance literature:: In N,N-dimethyl-formamide; at 140 ℃; for 16h;

Reference yield:

: methyl 8-nitroquinoline-7-carboxylate

: 1312166-07-6
6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclohexyl)pyrido[3,2-h]quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 6 h / 20 °C

2: bromine / 1,4-dioxane; tetrachloromethane / 2 h / 0 °C

3: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 0 - 20 °C

4: lithium hydroxide; water / methanol; tetrahydrofuran / 24.08 h / 0 - 20 °C

5: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

6: N,N-dimethyl-formamide / 16 h / 140 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium on activated charcoal; water; hydrogen; bromine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; N,N-dimethyl-formamide;