4-benzyl-2-[(3,4-dichloro-phenyl)-morpholin-2-yl]-acetaldehyde

Base Information

• Chemical Name: 4-benzyl-2-[(3,4-dichloro-phenyl)-morpholin-2-yl]-acetaldehyde
• CAS No.: 1360058-04-3
• Molecular Formula: C₁₉H₁₉Cl₂NO₂
• Molecular Weight: 364.271
• Mol file: 1360058-04-3.mol

Synonyms:4-benzyl-2-[(3,4-dichloro-phenyl)-morpholin-2-yl]-acetaldehyde

Chemical Property of 4-benzyl-2-[(3,4-dichloro-phenyl)-morpholin-2-yl]-acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyl-2-[(3,4-dichloro-phenyl)-morpholin-2-yl]-acetaldehyde

There total 8 articles about 4-benzyl-2-[(3,4-dichloro-phenyl)-morpholin-2-yl]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C20H21Cl2NO (1360058-02-1) → 4-benzyl-2-[(3,4-dichloro-phenyl)-morpholin-2-yl]-acetaldehyde (1360058-04-3)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; water; for 3.08333h;

DOI:10.1016/j.tet.2013.05.097

Reference yield:

C20H23Cl2NO3 → 4-benzyl-2-[(3,4-dichloro-phenyl)-morpholin-2-yl]-acetaldehyde (1360058-04-3)

Guidance literature:

With sodium periodate; In water; acetone; at 20 ℃; for 4h;

DOI:10.1055/s-0031-1289878

Reference yield:

4-benzyl-2-(3,4-dichlorophenyl)-2-methoxy-morpholin-3-one (1360057-99-3) → 4-benzyl-2-[(3,4-dichloro-phenyl)-morpholin-2-yl]-acetaldehyde (1360058-04-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylsilane; titanium tetrachloride / dichloromethane / 0.5 h / -78 °C

2.1: bis(η3-allyl-μ-chloropalladium(II)); n-butyllithium; N,N,N,N,-tetramethylethylenediamine; (1R,2R)-(+)-1,2-diaminocyclohexane-N,N’-bis(2-diphenylphosphino-1-naphthoyl) / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 12 h / -78 - 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

4.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 12 h / 20 °C

5.1: sodium periodate / water; acetone / 4 h / 20 °C

With triethylsilane; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; bis(η3-allyl-μ-chloropalladium(II)); N,N,N,N,-tetramethylethylenediamine; water; titanium tetrachloride; 4-methylmorpholine N-oxide; (1R,2R)-(+)-1,2-diaminocyclohexane-N,N’-bis(2-diphenylphosphino-1-naphthoyl); In tetrahydrofuran; dichloromethane; water; acetone;

DOI:10.1055/s-0031-1289878

upstream raw materials:

4-benzyl-2-(3,4-dichlorophenyl)-morpholin-3-one

2-allyl-4-benzyl-2-(3,4-dichloro-phenyl)-morpholin-3-one

C₂₀H₂₁Cl₂NO

4-benzyl-2-(3,4-dichlorophenyl)-2-hydroxy-morpholin-3-one