Cbz-L-α-methylvaline-t-Leu-Aib₄-GlyNH₂

Base Information

• Chemical Name: Cbz-L-α-methylvaline-t-Leu-Aib₄-GlyNH₂
• CAS No.: 1605397-56-5
• Molecular Formula: C₃₈H₆₂N₈O₉
• Molecular Weight: 774.958
• Mol file: 1605397-56-5.mol

Synonyms:Cbz-L-α-methylvaline-t-Leu-Aib₄-GlyNH₂

Chemical Property of Cbz-L-α-methylvaline-t-Leu-Aib₄-GlyNH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-L-α-methylvaline-t-Leu-Aib₄-GlyNH₂

There total 7 articles about Cbz-L-α-methylvaline-t-Leu-Aib₄-GlyNH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C24H45N7O6 (1605397-64-5) + Z-L-(αMe)Val-F (175224-23-4) → Cbz-L-α-methylvaline-t-Leu-Aib4-GlyNH2 (1605397-56-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 120h;

DOI:10.1021/jo500714b

Reference yield:

Cbz-t-Leu-Aib4-GlyNH2 (1605397-32-7) → Cbz-L-α-methylvaline-t-Leu-Aib4-GlyNH2 (1605397-56-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 120 h / 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

DOI:10.1021/jo500714b

Reference yield:

N3(α-aminoisobutyric acid)4OtBu (1187839-02-6) → Cbz-L-α-methylvaline-t-Leu-Aib4-GlyNH2 (1605397-56-5)

Guidance literature:

Multi-step reaction with 6 steps

1: trifluoroacetic acid / dichloromethane

2: acetic anhydride; triethylamine / acetonitrile / 120 °C / Heating

3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5: palladium on activated charcoal; hydrogen / methanol

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 120 h / 20 °C

With palladium 10% on activated carbon; palladium on activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; acetic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jo500714b

upstream raw materials:

C₂₄H₄₅N₇O₆

Z-L-(αMe)Val-F

Cbz-t-Leu-Aib₄-GlyNH₂

N₃(α-aminoisobutyric acid)₄OtBu

Refernces