Technology Process of [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine
There total 8 articles about [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine;
In
acetonitrile;
at 60 ℃;
DOI:10.1016/j.tetlet.2006.02.043
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 98 percent / H2SO4 / Heating
2: 99 percent / K2CO3; TBAI / acetone / Heating
3: 85 percent / HNO3; Ac2O / 20 °C
4: 100 percent / H2 / Pd/C / ethanol
5: 90 percent / 160 °C
6: 100 percent / POCl3; diisopropylethylamine / toluene / Heating
7: 100 percent / isopropanol / Heating
8: 37 percent / triethylamine; Pd(PPh3)4; CuI / acetonitrile / 60 °C
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); sulfuric acid; hydrogen; nitric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; trichlorophosphate;
palladium on activated charcoal;
In
ethanol; acetone; toluene; acetonitrile;
8: Sonogashira coupling reaction;
DOI:10.1016/j.tetlet.2006.02.043
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 99 percent / K2CO3; TBAI / acetone / Heating
2: 85 percent / HNO3; Ac2O / 20 °C
3: 100 percent / H2 / Pd/C / ethanol
4: 90 percent / 160 °C
5: 100 percent / POCl3; diisopropylethylamine / toluene / Heating
6: 100 percent / isopropanol / Heating
7: 37 percent / triethylamine; Pd(PPh3)4; CuI / acetonitrile / 60 °C
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); hydrogen; nitric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; trichlorophosphate;
palladium on activated charcoal;
In
ethanol; acetone; toluene; acetonitrile;
7: Sonogashira coupling reaction;
DOI:10.1016/j.tetlet.2006.02.043