[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine

Base Information

Chemical Name:[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine
CAS No.:882511-68-4
Molecular Formula:C₃₅H₄₆N₄O₄
Molecular Weight:586.775
Hs Code.:

Synonyms:[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine

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Chemical Property of [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine

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Technology Process of [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine

There total 8 articles about [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 882511-64-0
[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-iodo-phenyl)-amine

: N-cyclohexyl-N-(prop-2-yn-1-yl)cyclohexanamine

: 882511-68-4
[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In acetonitrile; at 60 ℃;
DOI:10.1016/j.tetlet.2006.02.043

Reference yield:

: 99-50-3
3,4-Dihydroxybenzoic acid

: 882511-68-4
[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / H₂SO₄ / Heating

2: 99 percent / K₂CO₃; TBAI / acetone / Heating

3: 85 percent / HNO₃; Ac₂O / 20 °C

4: 100 percent / H₂ / Pd/C / ethanol

5: 90 percent / 160 °C

6: 100 percent / POCl₃; diisopropylethylamine / toluene / Heating

7: 100 percent / isopropanol / Heating

8: 37 percent / triethylamine; Pd(PPh₃)4; CuI / acetonitrile / 60 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydrogen; nitric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; trichlorophosphate; palladium on activated charcoal; In ethanol; acetone; toluene; acetonitrile; 8: Sonogashira coupling reaction;
DOI:10.1016/j.tetlet.2006.02.043

Reference yield:

: 2150-43-8
3,4-dihydroxybenzoic acid methyl ester

: 882511-68-4
[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / K₂CO₃; TBAI / acetone / Heating

2: 85 percent / HNO₃; Ac₂O / 20 °C

3: 100 percent / H₂ / Pd/C / ethanol

4: 90 percent / 160 °C

5: 100 percent / POCl₃; diisopropylethylamine / toluene / Heating

6: 100 percent / isopropanol / Heating

7: 37 percent / triethylamine; Pd(PPh₃)4; CuI / acetonitrile / 60 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; nitric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; trichlorophosphate; palladium on activated charcoal; In ethanol; acetone; toluene; acetonitrile; 7: Sonogashira coupling reaction;
DOI:10.1016/j.tetlet.2006.02.043