2-{1-Methoxy-1-[2-methyl-5-(naphthalen-2-ylmethoxy)-phenyl]-ethyl}-thiazole

Base Information

Chemical Name:2-{1-Methoxy-1-[2-methyl-5-(naphthalen-2-ylmethoxy)-phenyl]-ethyl}-thiazole
CAS No.:134154-12-4
Molecular Formula:C₂₄H₂₃NO₂S
Molecular Weight:389.518
Hs Code.:

Synonyms:2-{1-Methoxy-1-[2-methyl-5-(naphthalen-2-ylmethoxy)-phenyl]-ethyl}-thiazole

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Chemical Property of 2-{1-Methoxy-1-[2-methyl-5-(naphthalen-2-ylmethoxy)-phenyl]-ethyl}-thiazole

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Technology Process of 2-{1-Methoxy-1-[2-methyl-5-(naphthalen-2-ylmethoxy)-phenyl]-ethyl}-thiazole

There total 6 articles about 2-{1-Methoxy-1-[2-methyl-5-(naphthalen-2-ylmethoxy)-phenyl]-ethyl}-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77324-87-9
methyl 2-methyl-5-nitrobenzoate

: 134154-12-4
2-{1-Methoxy-1-[2-methyl-5-(naphthalen-2-ylmethoxy)-phenyl]-ethyl}-thiazole

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 1520 - 2280 Torr

2: 64 percent / 5.4 volpercent H₂SO₄, aq. NaNO₂ / 0.5 h / Heating

3: 89 percent / K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

4: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 0.5 h, 2.) THF, ether, hexane, -70 deg C, 0.5 h

5: 90 percent / tetrahydrofuran / 1 h / Ambient temperature

6: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h

With n-butyllithium; sulfuric acid; hydrogen; sodium hydride; potassium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a038

Reference yield:

: 18595-12-5
methyl 5-amino-2-methylbenzoate

: 134154-12-4
2-{1-Methoxy-1-[2-methyl-5-(naphthalen-2-ylmethoxy)-phenyl]-ethyl}-thiazole

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / 5.4 volpercent H₂SO₄, aq. NaNO₂ / 0.5 h / Heating

2: 89 percent / K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

3: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 0.5 h, 2.) THF, ether, hexane, -70 deg C, 0.5 h

4: 90 percent / tetrahydrofuran / 1 h / Ambient temperature

5: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h

With n-butyllithium; sulfuric acid; sodium hydride; potassium carbonate; sodium nitrite; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a038

Reference yield:

: 73505-48-3
methyl 3-hydroxy-6-methylbenzoate

: 134154-12-4
2-{1-Methoxy-1-[2-methyl-5-(naphthalen-2-ylmethoxy)-phenyl]-ethyl}-thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

2: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 0.5 h, 2.) THF, ether, hexane, -70 deg C, 0.5 h

3: 90 percent / tetrahydrofuran / 1 h / Ambient temperature

4: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h

With n-butyllithium; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a038