N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-9H-purin-2-yl]-isobutyramide

Base Information

• Chemical Name: N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-9H-purin-2-yl]-isobutyramide
• CAS No.: 903905-79-3
• Molecular Formula: C₄₆H₆₃N₉O₅Si₂
• Molecular Weight: 878.235
• Mol file: 903905-79-3.mol

Synonyms:N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-9H-purin-2-yl]-isobutyramide

Chemical Property of N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-9H-purin-2-yl]-isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-9H-purin-2-yl]-isobutyramide

There total 2 articles about N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-9H-purin-2-yl]-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (105650-23-5) + N2-iso-butyryl-O6-benzyl-8-bromo-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (444594-32-5) → N-[8-bromo-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-9H-purin-2-yl]-isobutyramide + N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-9H-purin-2-yl]-isobutyramide (903905-79-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; In toluene; at 100 ℃; for 0.333333h;

DOI:10.1021/tx0600191

Reference yield:

6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine (896719-58-7) + isobutyryl chloride (79-30-1) → N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-9H-purin-2-yl]-isobutyramide (903905-79-3)

Guidance literature:

With dmap; In pyridine;

DOI:10.1021/tx0600191

Reference yield:

N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-9H-purin-2-yl]-isobutyramide (903905-79-3) → N-[9-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-6-oxo-6,9-dihydro-1H-purin-2-yl]-isobutyramide (903905-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1: HF / pyridine

2: H₂ / Pd(OH)2 / methanol

With hydrogen fluoride; hydrogen; palladium dihydroxide; In pyridine; methanol;

DOI:10.1021/tx0600191

upstream raw materials:

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

N²-iso-butyryl-O⁶-benzyl-8-bromo-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine

isobutyryl chloride

Downstream raw materials:

N-[9-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-6-oxo-6,9-dihydro-1H-purin-2-yl]-isobutyramide