2-amino-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-5-(piperidin-1-yl)-benzamide

Base Information

Chemical Name:2-amino-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-5-(piperidin-1-yl)-benzamide
CAS No.:1354722-08-9
Molecular Formula:C₂₃H₂₇N₅O
Molecular Weight:389.5
Hs Code.:

Synonyms:2-amino-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-5-(piperidin-1-yl)-benzamide

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Chemical Property of 2-amino-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-5-(piperidin-1-yl)-benzamide

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Technology Process of 2-amino-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-5-(piperidin-1-yl)-benzamide

There total 5 articles about 2-amino-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-5-(piperidin-1-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1354722-06-7
N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-2-nitro-5-(piperidin-1-yl)-benzamide

: 1354722-08-9
2-amino-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-5-(piperidin-1-yl)-benzamide

Guidance literature:: N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-2-nitro-5-(piperidin-1-yl)-benzamide; With acetic acid; zinc; at 70 ℃; for 1h;

With ammonia; pH=8;

Reference yield:

: 583-71-1
4-bromo-o-xylene

: 1354722-08-9
2-amino-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-5-(piperidin-1-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 20 °C

3.1: pyridine / dichloromethane / 2 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 110 °C

5.1: zinc; acetic acid / 1 h / 70 °C

5.2: pH 8

With pyridine; copper(l) iodide; hydrogen; potassium carbonate; acetic acid; L-proline; zinc; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1354722-01-2
1-(3,4-dimethylphenyl)-3-nitro-1H-pyrazole

: 1354722-08-9
2-amino-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-5-(piperidin-1-yl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 20 °C

2.1: pyridine / dichloromethane / 2 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 110 °C

4.1: zinc; acetic acid / 1 h / 70 °C

4.2: pH 8

With pyridine; hydrogen; potassium carbonate; acetic acid; zinc; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;