tert-butyl 3-((3-((2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoate

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Chemical Name:tert-butyl 3-((3-((2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoate
CAS No.:1354722-10-3
Molecular Formula:C₃₈H₄₅N₅O₄S
Molecular Weight:667.872
Hs Code.:

Synonyms:tert-butyl 3-((3-((2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoate

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Chemical Property of tert-butyl 3-((3-((2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoate

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Technology Process of tert-butyl 3-((3-((2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoate

There total 9 articles about tert-butyl 3-((3-((2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1354652-72-4
3-((3-tert-butoxy-3-oxopropylthio)methyl)benzoic acid

: 1354722-08-9
2-amino-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-5-(piperidin-1-yl)-benzamide

: 1354722-10-3
tert-butyl 3-((3-((2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 583-71-1
4-bromo-o-xylene

: 1354722-10-3
tert-butyl 3-((3-((2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 20 °C

3.1: pyridine / dichloromethane / 2 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 110 °C

5.1: zinc; acetic acid / 1 h / 70 °C

5.2: pH 8

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

With pyridine; dmap; copper(l) iodide; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; L-proline; zinc; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1354722-01-2
1-(3,4-dimethylphenyl)-3-nitro-1H-pyrazole

: 1354722-10-3
tert-butyl 3-((3-((2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 20 °C

2.1: pyridine / dichloromethane / 2 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 110 °C

4.1: zinc; acetic acid / 1 h / 70 °C

4.2: pH 8

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

With pyridine; dmap; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;