5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole

Base Information

Chemical Name:5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole
CAS No.:317319-28-1
Molecular Formula:C11H9 Cl2 N S
Molecular Weight:258.171
Hs Code.:2934100090
DSSTox Substance ID:DTXSID40377102
Wikidata:Q82166168
Mol file:317319-28-1.mol

Synonyms:317319-28-1;5-(chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole;5-(Chloromethyl)-2-(4-chlorophenyl)-4-methylthiazole;5-chloromethyl-2-(4-chlorophenyl)-4-methylthiazole;5-(chloromethyl)-4-methyl-2-(4-chlorophenyl)thiazole;SCHEMBL2069618;DTXSID40377102;GZXHFIJLAGIXIN-UHFFFAOYSA-N;MFCD03791197;AKOS005070073;FT-0680236;2W-0316;J-516312

Suppliers and Price of 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole >95%
5g
$ 750.00

Crysdot
5-(Chloromethyl)-2-(4-chlorophenyl)-4-methylthiazole 95+%
1g
$ 301.00

Crysdot
5-(Chloromethyl)-2-(4-chlorophenyl)-4-methylthiazole 95+%
5g
$ 691.00

Chemenu
5-(Chloromethyl)-2-(4-chlorophenyl)-4-methylthiazole 95%
5g
$ 653.00

American Custom Chemicals Corporation
5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE 95.00%
10G
$ 1766.00

American Custom Chemicals Corporation
5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE 95.00%
5G
$ 1233.77

Alichem
5-(Chloromethyl)-2-(4-chlorophenyl)-4-methylthiazole
5g
$ 718.94

AK Scientific
5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole
500mg
$ 401.00

Total 11 raw suppliers

Chemical Property of 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole

Chemical Property:

Vapor Pressure:6.28E-06mmHg at 25°C
Melting Point:109-112°C
Refractive Index:1.607
Boiling Point:389.7°Cat760mmHg
Flash Point:189.5°C
PSA：41.13000
Density:1.335g/cm³
LogP:4.51070
XLogP3:4.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:256.9832759
Heavy Atom Count:15
Complexity:207

Purity/Quality:

97% ^*data from raw suppliers

5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(SC(=N1)C2=CC=C(C=C2)Cl)CCl

Technology Process of 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole

There total 4 articles about 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 317319-22-5
(2-(4-chlorophenyl)-4-methylthiazol-5-yl)methanol

: 317319-28-1
5-chloromethyl-2-(4-chloro-phenyl)-4-methyl-thiazole

Guidance literature:: With thionyl chloride; In chloroform; at -10 ℃; for 0.5h;

Reference yield:

: 54001-12-6
ethyl 2-(4-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate

: 317319-28-1
5-chloromethyl-2-(4-chloro-phenyl)-4-methyl-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / Reflux

2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 40 °C

With sodium tetrahydroborate; thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2016.02.040

Reference yield:

: 2521-24-6
4-chlorothiobenzamide

: 317319-28-1
5-chloromethyl-2-(4-chloro-phenyl)-4-methyl-thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 6 h / Reflux

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / Reflux

3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 40 °C

With sodium tetrahydroborate; thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2016.02.040