54001-12-6

Basic information

• Product Name: ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
• Synonyms: ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE;Ethyl4-methyl-2-(4-chlorophenyl)thiazole-5-carboxylate
• CAS NO: 54001-12-6
• Molecular Formula: C₁₃H₁₂ClNO₂S
• Molecular Weight: 281.76
• Mol File: 54001-12-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 83-85°C
• Boiling Point: 396.4°C at 760 mmHg
• Flash Point: 193.6°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 1.71E-06mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(54001-12-6)
• EPA Substance Registry System: ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(54001-12-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 54001-12-6(Hazardous Substances Data)

Usage

General Description

ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE is a chemical compound with a complex molecular structure. It is an ester containing an ethyl group, a substituted thiazole ring, and a carboxylate group. The compound also contains a chlorine atom attached to the phenyl group. This chemical is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and properties make it a valuable intermediate in the production of various products. Caution should be taken when handling this compound, as it may be hazardous if not used properly.

InChI:InChI=1/C13H12ClNO2S/c1-3-17-13(16)11-8(2)15-12(18-11)9-4-6-10(14)7-5-9/h4-7H,3H2,1-2H3

Upstream product

• 7210-76-6 ethyl-2-amino-4-methylthiazole-5-carboxylate 
• 53137-15-8 ethyl 2-iodo-4-methylthiazole-5-carboxylate 
• 1679-18-1 4-Chlorophenylboronic acid 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 623-03-0 4-Cyanochlorobenzene 
• 84911-18-2 ethyl 2-bromoacetoacetate 
• 2521-24-6 4-chlorothiobenzamide 
• 619-56-7 4-chlorobenzamide 
• 638-07-3 ethyl (2-chloroaceto)acetate 

Downstream Products

• 54001-29-5 1-[2-(4-chloro-phenyl)-4-methyl-thiazol-5-yl]-2-diazo-ethanone 
• 54000-89-4 2-chloro-1-[2-(4-chloro-phenyl)-4-methyl-thiazol-5-yl]-ethanone 
• 54001-07-9 1-(4-methyl-2-(4'-chlorophenyl)thiazole-5-yl)ethane-1-one 
• 54001-36-4 2-bromo-1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]-1-ethanone 
• 1384111-06-1 C₁₅H₁₅ClN₂O₃S 
• 317319-28-1 5-chloromethyl-2-(4-chloro-phenyl)-4-methyl-thiazole 
• 685541-32-6 2-(4-chlorophenyl)-4-methylthiazole-5-carbohydrazide 

Relevant articles and documents

Synthesis of novel thiazol-5-ylpyrimidine derivatives and their antimicrobial evaluation

Novel thiazol-5-ylpyrimidine derivatives were designed and synthesized. The chemical structures of all new synthesized compounds were assigned by studying their elemental analyses and spectral data (FT-IR, 1HNMR, 13C NMR, and MS). Th

Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity

A series of novel thiazolyl hydrazine derivatives 3a-3o were synthesized and evaluated for their in vitro antifungal activity against six phytopathogenic strains, namely, Botryosphaeria dothidea (B. d.), Gibberella sanbinetti (G. s.), Fusarium oxysporum (F. o.), Thanatephorus cucumeris (T. c.), Sclerotinia sclerotiorum (S. s.), and Verticillium dahliae (V. d.), by the classical mycelial growth rate method. Biological assessment results showed that most of these target compounds showed good antifungal activity toward tested strains. Especially, compound 3l showed excellent antifungal activities against B. d. and G. s. with relatively lower EC50 values of 0.59 and 0.69 μg/mL, respectively, which were extremely superior to those of commercial fungicides fluopyram, boscalid, and hymexazol and were comparable to those of carbendazim. Given the excellent bioactivity of designed compounds, this kind of thiazolyl hydrazine framework can provide a suitable point for exploring highly efficient antifungal agents.

Synthesis and Antimicrobial Activity of New 3-(2-(4-Chlorophenyl)-4-methylthiazol-5-yl) substituted- isoxazol-5-amine, 1-phenyl-1H-pyrazol-5-amine, and their Derivatives

New 3-(2-(4-chlorophenyl)-4-methylthiazol-5-yl) substituted aminoisoxazole, aminopyrazole, and their appropriate urea and amide analogs were prepared from thiazole substituted oxopropanenitrile. The structures of newly synthesized compounds were illustrat