(R)-(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-fluorobenzyl)quinolin-3-yl)methanone

Base Information

Chemical Name:(R)-(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-fluorobenzyl)quinolin-3-yl)methanone
CAS No.:1308339-08-3
Molecular Formula:C₂₉H₂₇FN₂O₃
Molecular Weight:470.543
Hs Code.:

Synonyms:(R)-(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-fluorobenzyl)quinolin-3-yl)methanone

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Chemical Property of (R)-(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-fluorobenzyl)quinolin-3-yl)methanone

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Technology Process of (R)-(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-fluorobenzyl)quinolin-3-yl)methanone

There total 3 articles about (R)-(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-fluorobenzyl)quinolin-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 312693-05-3
(2-fluorobenzyl)zinc(II) chloride

: 1308339-07-2
(R)-(2-chloroquinolin-3-yl)(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone

: 1308339-08-3
(R)-(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-fluorobenzyl)quinolin-3-yl)methanone

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; Inert atmosphere;

Reference yield:

: 73568-25-9
2-chloro-3-quinoline carboxaldehyde

: 1308339-08-3
(R)-(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-fluorobenzyl)quinolin-3-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium chlorite; sodium dihydrogenphosphate dihydrate / acetonitrile / 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 60 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate dihydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 73776-25-7
2-chloro-3-quinolinecarboxylic acid

: 1308339-08-3
(R)-(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-fluorobenzyl)quinolin-3-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 60 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;