3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile

Base Information

Chemical Name:3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile
CAS No.:1034694-21-7
Molecular Formula:C₁₂H₁₀ClF₂NO₃
Molecular Weight:289.666
Hs Code.:

Synonyms:3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile

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Chemical Property of 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile

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Technology Process of 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile

There total 5 articles about 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1034694-53-5
2-(2-chloro-5-(difluoromethoxy)phenyl)-3-hydroxypropanenitrile

: 108-24-7
acetic anhydride

: 1034694-21-7
3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile

Guidance literature:: With sulfuric acid; In acetonitrile; for 0.25h;

Reference yield:

: 59-50-7
4-Chloro-3-methylphenol

: 1034694-21-7
3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / tetrabutylammonium sulfate / tetrahydrofuran; water / 1.5 h / 30 - 40 °C

2: tetrachloromethane; N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 4 h / Heating / reflux

3: hydrogenchloride / water; N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C

4: N-benzyl-trimethylammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; ethanol / 0.83 h / 20 °C

5: sulfuric acid / acetonitrile / 0.25 h

With hydrogenchloride; tetrachloromethane; potassium hydroxide; N-Bromosuccinimide; sulfuric acid; N-benzyl-trimethylammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrabutylammonium sulfate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 380348-24-3
2-chloro-5-(difluoromethoxy)toluene

: 1034694-21-7
3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tetrachloromethane; N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 4 h / Heating / reflux

2: hydrogenchloride / water; N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C

3: N-benzyl-trimethylammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; ethanol / 0.83 h / 20 °C

4: sulfuric acid / acetonitrile / 0.25 h

With hydrogenchloride; tetrachloromethane; N-Bromosuccinimide; sulfuric acid; N-benzyl-trimethylammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; dibenzoyl peroxide; In methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;