Technology Process of 2-<2'-(N,N-dimethylamino)ethoxy>-3-<(E)-4-hexenyl>-1,4-cyclohexadiene
There total 4 articles about 2-<2'-(N,N-dimethylamino)ethoxy>-3-<(E)-4-hexenyl>-1,4-cyclohexadiene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
a) -78 deg C, 0.5 h, b) -78 deg C, 20 min, c) room temperature, 3h;
DOI:10.1021/jo00014a040
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 62 percent / lithium amide / liquid ammonia
2: 86 percent / Na / liquid ammonia
3: triethylamine / tetrahydrofuran / 1) 30 min, 0 deg C, 2) 30 min, room temperature
4: anhydrous LiBr / tetrahydrofuran / 4 h / Heating
5: 87 percent / n-butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide / a) -78 deg C, 0.5 h, b) -78 deg C, 20 min, c) room temperature, 3h
With
n-butyllithium; lithium amide; sodium; triethylamine; lithium bromide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ammonia;
DOI:10.1021/jo00014a040
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86 percent / Na / liquid ammonia
2: triethylamine / tetrahydrofuran / 1) 30 min, 0 deg C, 2) 30 min, room temperature
3: anhydrous LiBr / tetrahydrofuran / 4 h / Heating
4: 87 percent / n-butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide / a) -78 deg C, 0.5 h, b) -78 deg C, 20 min, c) room temperature, 3h
With
n-butyllithium; sodium; triethylamine; lithium bromide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ammonia;
DOI:10.1021/jo00014a040
