<<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane

Base Information

Chemical Name:<<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane
CAS No.:123836-64-6
Molecular Formula:C₃₆H₆₅FO₂Si₂
Molecular Weight:605.08
Hs Code.:

Synonyms:<<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane

Suppliers and Price of <<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of <<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of <<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane

There total 15 articles about <<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123836-61-3
<3S-(1Z,3β,5α)>-<3-Fluoro-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>ethanol

: 123836-64-6
<<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / N-chlorosuccinimide, dimethyl sulfide / CH₂Cl₂ / 0.5 h / -20 °C

2: 1.)0.338 M lithium diphenylphosphide, 2.)5percent H₂O₂ / 1.)THF, -75 deg C, 2.)CH₂Cl₂, R_.T_., 45 min.

3: 1.)n-BuLi / 1.)THF, -75 deg C, 6 min., 2.)THF, -75 deg C, 5 h

With N-chloro-succinimide; n-butyllithium; dimethylsulfide; dihydrogen peroxide; lithium diphenylphosphide; In dichloromethane;
DOI:10.1021/jo00288a040

Reference yield:

: 123836-59-9
<3R-(1E,3α,5α)>-<3-Hydroxy-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic Acid Ethyl Ester

: 123836-64-6
<<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / (diethylamido)sulfur trifluoride / CH₂Cl₂ / 0.5 h / -95 °C

2: 85 percent / fluorenone / various solvent(s) / 1 h / Irradiation

3: 83 percent / diisobutylaluminum hydride / toluene / 40 h / -75 °C

4: 93 percent / N-chlorosuccinimide, dimethyl sulfide / CH₂Cl₂ / 0.5 h / -20 °C

5: 1.)0.338 M lithium diphenylphosphide, 2.)5percent H₂O₂ / 1.)THF, -75 deg C, 2.)CH₂Cl₂, R_.T_., 45 min.

6: 1.)n-BuLi / 1.)THF, -75 deg C, 6 min., 2.)THF, -75 deg C, 5 h

With N-chloro-succinimide; n-butyllithium; 9-fluorenone; dimethylsulfide; (diethylamido)sulfur trifluoride; dihydrogen peroxide; diisobutylaluminium hydride; lithium diphenylphosphide; In dichloromethane; toluene;
DOI:10.1021/jo00288a040

Reference yield:

: 123836-51-1
<2S-(1E,2α,3α,5α)>-<3-(Acetyloxy)-2-hydroxy-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic Acid Ethyl Ester

: 123836-64-6
<<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane

Guidance literature:: Multi-step reaction with 14 steps

1: 100 percent / 4-(dimethylamino)pyridine / pyridine / 72 h / 25 °C

2: 83 percent / 1percent aq. OsO₄, potassium periodate / tetrahydrofuran; H₂O / 31 h / 25 °C

3: 93 percent / 90percent H₂O₂, trifluoracetic anhydride, KH₂PO₄ / CH₂Cl₂ / 23 h / 0 °C

4: 58 percent / cation-exchange resin AG 50W-X₄ / ethanol / 21 h / 25 °C

5: 96 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

6: 100 percent / Zn, 1M KH₂PO₄ / tetrahydrofuran / 4.5 h / 25 °C

7: 99 percent / bis<α,α-bis(trifluoromethyl)benzenemethanolato>diphenylsulfur / CCl4 / 1.5 h / 25 °C

8: 87 percent / 1.09M NaOEt / ethanol / 0.5 h / 25 °C

9: 60 percent / (diethylamido)sulfur trifluoride / CH₂Cl₂ / 0.5 h / -95 °C

10: 85 percent / fluorenone / various solvent(s) / 1 h / Irradiation

11: 83 percent / diisobutylaluminum hydride / toluene / 40 h / -75 °C

12: 93 percent / N-chlorosuccinimide, dimethyl sulfide / CH₂Cl₂ / 0.5 h / -20 °C

13: 1.)0.338 M lithium diphenylphosphide, 2.)5percent H₂O₂ / 1.)THF, -75 deg C, 2.)CH₂Cl₂, R_.T_., 45 min.

14: 1.)n-BuLi / 1.)THF, -75 deg C, 6 min., 2.)THF, -75 deg C, 5 h

With 1H-imidazole; dmap; potassium dihydrogenphosphate; N-chloro-succinimide; osmium(VIII) oxide; n-butyllithium; potassium metaperiodate; Martins sulfurane; 9-fluorenone; dimethylsulfide; (diethylamido)sulfur trifluoride; cation-exchange resin AG 50W-X₄; dihydrogen peroxide; sodium ethanolate; diisobutylaluminium hydride; lithium diphenylphosphide; trifluoroacetic anhydride; zinc; In tetrahydrofuran; pyridine; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00288a040