Methyl 3-(diphenylmethoxy)-5-isoxazolecarboxylate

Base Information

Chemical Name:Methyl 3-(diphenylmethoxy)-5-isoxazolecarboxylate
CAS No.:205115-25-9
Molecular Formula:C₁₈H₁₅NO₄
Molecular Weight:309.321
Hs Code.:
DSSTox Substance ID:DTXSID501230958

Synonyms:DTXSID501230958;205115-25-9;Methyl 3-(diphenylmethoxy)-5-isoxazolecarboxylate;InChI=1/C18H15NO4/c1-21-18(20)15-12-16(19-23-15)22-17(13-8-4-2-5-9-13)14-10-6-3-7-11-14/h2-12,17H,1H

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Chemical Property of Methyl 3-(diphenylmethoxy)-5-isoxazolecarboxylate

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:309.10010796
Heavy Atom Count:23
Complexity:359

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=CC(=NO1)OC(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Methyl 3-(diphenylmethoxy)-5-isoxazolecarboxylate

There total 4 articles about Methyl 3-(diphenylmethoxy)-5-isoxazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 776-74-9
Bromodiphenylmethane

: 10068-07-2
methyl 3-hydroxy-5-isoxazolecarboxylate

: 205115-25-9
3-Benzhydryloxy-isoxazole-5-carboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In acetone; 3 h, 70 deg C; 12 h, 20 deg C;
DOI:10.1002/(SICI)1099-0690(199803)1998:3<473::AID-EJOC473>3.0.CO;2-V

Reference yield: 53.0%

: 908093-98-1
diazodiphenylmethane

: 10068-07-2
methyl 3-hydroxy-5-isoxazolecarboxylate

: 205115-25-9
3-Benzhydryloxy-isoxazole-5-carboxylic acid methyl ester

Guidance literature:: In dichloromethane; for 1h;

Reference yield:

: 205115-22-6
3-benzyloxyisoxazole-5-carboxylic acid methyl ester

: 205115-25-9
3-Benzhydryloxy-isoxazole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / NBS, AIBN / CCl₄ / 2 h / Heating

2: 94 percent / K₂CO₃ / acetone / 3 h, 70 deg C; 12 h, 20 deg C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrachloromethane; acetone;
DOI:10.1002/(SICI)1099-0690(199803)1998:3<473::AID-EJOC473>3.0.CO;2-V