Technology Process of (7E)-1-hydroxy-5-methyloxycarbonyl-2,2,8,12-tetramethyl-5-phenylseleno-7,11-tridecadiene
There total 8 articles about (7E)-1-hydroxy-5-methyloxycarbonyl-2,2,8,12-tetramethyl-5-phenylseleno-7,11-tridecadiene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 12h;
DOI:10.1016/S0040-4020(01)96076-4
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature
2: 72 percent / sodium hydride / dimethylsulfoxide / room temp., 10 min. then 60 deg C, 6 h.
3: 95 percent / diethyl ether
4: 95 percent / H2 / 10percent Pd-C / ethyl acetate / 0.75 h
5: 70 percent / lithium diisopropylamide, hexamethylphosphoric triamide / tetrahydrofuran / 2 h / -80 °C
6: 85 percent / lithium diisopropylamide, hexamethylphosphoric triamide / tetrahydrofuran / 12 h / -78 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; sodium hydride; pyridinium chlorochromate; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/S0040-4020(01)96076-4
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / sodium hydride / dimethylsulfoxide / room temp., 10 min. then 60 deg C, 6 h.
2: 95 percent / diethyl ether
3: 95 percent / H2 / 10percent Pd-C / ethyl acetate / 0.75 h
4: 70 percent / lithium diisopropylamide, hexamethylphosphoric triamide / tetrahydrofuran / 2 h / -80 °C
5: 85 percent / lithium diisopropylamide, hexamethylphosphoric triamide / tetrahydrofuran / 12 h / -78 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; sodium hydride; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/S0040-4020(01)96076-4
