1-[6-(hydroxy-di-p-tolyl-methyl)-pyridin-2-yl]-2-pyridin-2-yl-ethanol

Base Information

• Chemical Name: 1-[6-(hydroxy-di-p-tolyl-methyl)-pyridin-2-yl]-2-pyridin-2-yl-ethanol
• CAS No.: 539836-30-1
• Molecular Formula: C₂₇H₂₄N₂O₂
• Molecular Weight: 408.5
• Mol file: 539836-30-1.mol

Synonyms:1-[6-(hydroxy-di-p-tolyl-methyl)-pyridin-2-yl]-2-pyridin-2-yl-ethanol

Chemical Property of 1-[6-(hydroxy-di-p-tolyl-methyl)-pyridin-2-yl]-2-pyridin-2-yl-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[6-(hydroxy-di-p-tolyl-methyl)-pyridin-2-yl]-2-pyridin-2-yl-ethanol

There total 4 articles about 1-[6-(hydroxy-di-p-tolyl-methyl)-pyridin-2-yl]-2-pyridin-2-yl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

α-picoline (109-06-8) + 6-(hydroxy-di-p-tolyl-methyl)-pyridine-2-carboxylic acid methyl ester (539836-27-6) → 1-[6-(hydroxy-di-p-tolyl-methyl)-pyridin-2-yl]-2-pyridin-2-yl-ethanol (539836-30-1)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(03)00141-2

Reference yield:

2,6-bis(methoxycarbonyl)pyridine (5453-67-8) → 1-[6-(hydroxy-di-p-tolyl-methyl)-pyridin-2-yl]-2-pyridin-2-yl-ethanol (539836-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / tetrahydrofuran / 3 h / -78 - 20 °C

2: 83 percent / BuLi / tetrahydrofuran / 1.5 h / -40 °C

With n-butyllithium; In tetrahydrofuran;

DOI:10.1016/j.tet.2005.04.060

Reference yield:

para-methylphenylmagnesium bromide (4294-57-9) → 1-[6-(hydroxy-di-p-tolyl-methyl)-pyridin-2-yl]-2-pyridin-2-yl-ethanol (539836-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / tetrahydrofuran / 3 h / -78 - 20 °C

2: 83 percent / BuLi / tetrahydrofuran / 1.5 h / -40 °C

With n-butyllithium; In tetrahydrofuran;

DOI:10.1016/j.tet.2005.04.060

upstream raw materials:

α-picoline

6-(hydroxy-di-p-tolyl-methyl)-pyridine-2-carboxylic acid methyl ester

2,6-bis(methoxycarbonyl)pyridine

para-methylphenylmagnesium bromide

Downstream raw materials:

methyl 6-O-[6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methyl-α-D-glucopyranoside

[6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methanol

[6-(2-pyridin-2-yl-vinyl)-pyridin-2-yl]-di-p-tolyl-methanol

1-[6-(hydroxy-di-p-tolyl-methyl)-pyridin-2-yl]-2-pyridin-2-yl-ethanol