3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclopentane carboxylic acid

Base Information

Chemical Name:3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclopentane carboxylic acid
CAS No.:1332706-64-5
Molecular Formula:C₂₅H₂₁ClN₂O₃
Molecular Weight:432.906
Hs Code.:

Synonyms:3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclopentane carboxylic acid

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Chemical Property of 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclopentane carboxylic acid

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Technology Process of 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclopentane carboxylic acid

There total 10 articles about 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclopentane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332706-95-2
ethyl 3-{[5-(biphenyl-4-yl)-6-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl]oxy}cyclopentanecarboxylate

: 1332706-64-5
3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclopentane carboxylic acid

Guidance literature:: ethyl 3-{[5-(biphenyl-4-yl)-6-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl]oxy}cyclopentanecarboxylate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 80 ℃; for 5.5h;

With water; sodium hydroxide; In methanol; at 20 ℃;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 1332706-64-5
3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclopentane carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid; N-iodo-succinimide / 50 °C

2.1: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

3.1: potassium hydroxide / ethanol / 3 h / Reflux

4.1: potassium carbonate / acetone / 0 - 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

6.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C

7.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 80 °C

9.2: 20 °C

9.3: pH 1

With potassium phosphate; N-iodo-succinimide; tetrabutyl ammonium fluoride; iron; potassium carbonate; ammonium chloride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 335349-57-0
2-nitro-4-iodo-5-chloroaniline

: 1332706-64-5
3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclopentane carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

2.1: potassium hydroxide / ethanol / 3 h / Reflux

3.1: potassium carbonate / acetone / 0 - 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 20 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 80 °C

8.2: 20 °C

8.3: pH 1

With potassium phosphate; tetrabutyl ammonium fluoride; iron; potassium carbonate; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;