N-cycIopropyl-3-fluoro-5-(4-formyl-2-(3-hydroxy-2,2-dmethylpropyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Base Information

Chemical Name:N-cycIopropyl-3-fluoro-5-(4-formyl-2-(3-hydroxy-2,2-dmethylpropyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide
CAS No.:1220229-27-5
Molecular Formula:C₂₆H₂₇FN₂O₄
Molecular Weight:450.51
Hs Code.:

Synonyms:N-cycIopropyl-3-fluoro-5-(4-formyl-2-(3-hydroxy-2,2-dmethylpropyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

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Chemical Property of N-cycIopropyl-3-fluoro-5-(4-formyl-2-(3-hydroxy-2,2-dmethylpropyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

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Technology Process of N-cycIopropyl-3-fluoro-5-(4-formyl-2-(3-hydroxy-2,2-dmethylpropyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

There total 3 articles about N-cycIopropyl-3-fluoro-5-(4-formyl-2-(3-hydroxy-2,2-dmethylpropyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 585544-29-2
N-cyclopropyl-5-fluoro-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide

: 1220229-23-1
6-bromo-2-(3-chloro-2,2-dimethylpropyl)-1-oxo-1,2-dihydroisoquinoline-4-carbaldehyde

: 1220229-27-5
N-cycIopropyl-3-fluoro-5-(4-formyl-2-(3-hydroxy-2,2-dmethylpropyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Guidance literature:: 6-bromo-2-(3-chloro-2,2-dimethylpropyl)-1-oxo-1,2-dihydroisoquinoline-4-carbaldehyde; With potassium acetate; In 1-methyl-pyrrolidin-2-one; at 130 ℃; for 20h; Inert atmosphere;

N-cyclopropyl-5-fluoro-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide; With potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

: 585544-29-2
N-cyclopropyl-5-fluoro-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide

: 1220229-25-3
3-(6-bromo-4-formyl-1-oxoisoquinolin-2(1H)-yI)-2,2-dimethylpropyl acetate

: 1220229-27-5
N-cycIopropyl-3-fluoro-5-(4-formyl-2-(3-hydroxy-2,2-dmethylpropyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Guidance literature:: With potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In N,N-dimethyl-formamide; at 70 ℃; for 6h; Inert atmosphere;

Reference yield:

: 585544-29-2
N-cyclopropyl-5-fluoro-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide

: 1220229-54-8
6-bromo-2-(3-hydroxy-2,2-dimethylpropyl)-1-oxo-1,2-dihydroisoquinoline-4-carbaldehyde

: 1220229-27-5
N-cycIopropyl-3-fluoro-5-(4-formyl-2-(3-hydroxy-2,2-dmethylpropyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Guidance literature:: With potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In N,N-dimethyl-formamide; at 70 ℃; for 4h; Inert atmosphere;