Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate

Base Information Edit

Chemical Name:Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate
CAS No.:313657-51-1
Molecular Formula:C15H22 N2 O3
Molecular Weight:278.351
Hs Code.:2933599090
DSSTox Substance ID:DTXSID50468333
Wikidata:Q82295500
Mol file:313657-51-1.mol

Synonyms:313657-51-1;Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate;1-(2-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;1-BOC-4-(2-HYDROXY-PHENYL)-PIPERAZINE;1-BOC-4-(2-HYDROXYPHENYL)PIPERAZINE;MFCD04115062;1-(2-Hydroxyphenyl)-4-(tert-butoxycarbonyl)piperazine;4-(2-Hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester;SCHEMBL2382922;2-(4-Boc-1-piperazinyl)phenol;DTXSID50468333;YSJQUDZWTWSGNT-UHFFFAOYSA-N;1-Boc-4(2-hydroxyphenyl)-piperazine;AKOS014476251;AB19545;AS-36809;SY240392;CS-0060948;FT-0730672;EN300-204410;A820818;N-(2-hydroxyphenyl)-4-t-butoxycarbonyl-piperazine;1-(Hydroxyphenyl)-4-(tertbutyloxycarbonyl)piperazine;tert-Butyl 4-(2-hydroxyphenyl)-1-piperazinecarboxylate

Suppliers and Price of Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(2-Hydroxyphenyl)-4-(tert-butoxycarbonyl)piperazine
1g
$ 155.00

Medical Isotopes, Inc.
1-(2-Hydroxyphenyl)-4-(tert-butoxycarbonyl)piperazine
1 g
$ 640.00

Labseeker
1-(2-hydroxy-phenyl)-piperazine-4-carboxylicacidtert-butylester 95
1g
$ 308.00

J&W Pharmlab
1-Boc-4-(2-hydroxy-phenyl)-piperazine 96%
25g
$ 525.00

J&W Pharmlab
1-Boc-4-(2-hydroxy-phenyl)-piperazine 96%
5g
$ 150.00

J&W Pharmlab
1-Boc-4-(2-hydroxy-phenyl)-piperazine 96%
1g
$ 50.00

American Custom Chemicals Corporation
1-(2-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00%
5G
$ 1940.40

Alichem
1-(2-Hydroxy-phenyl)-piperazine-4-carboxylicacidtert-butylester
5g
$ 160.50

AK Scientific
1-(2-Hydroxy-phenyl)-piperazine-4-carboxylicacidtert-butylester
25g
$ 751.00

AK Scientific
1-(2-Hydroxy-phenyl)-piperazine-4-carboxylicacidtert-butylester
5g
$ 251.00

Total 10 raw suppliers

Chemical Property of Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate Edit

Chemical Property:

Boiling Point:403.2±40.0 °C(Predicted)
PKA:11.25±0.35(Predicted)
PSA：53.01000
Density:1.167±0.06 g/cm3(Predicted)
LogP:2.45220
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:278.16304257
Heavy Atom Count:20
Complexity:333

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Hydroxyphenyl)-4-(tert-butoxycarbonyl)piperazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCN(CC1)C2=CC=CC=C2O
Uses 1-(2-Hydroxyphenyl)-4-(tert-butoxycarbonyl)piperazine is an intermediate used to synthesize 2-(1-Piperazinyl)-benzenethiol (P480550) which is used to used to prepare 3,5-dioxo-(2H,4H)-1,2,4-triazine as 5-HT1AR ligands. 1-(2-Hydroxyphenyl)-4-(tert-butoxycarbonyl)piperazine is also used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis.

Technology Process of Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate

There total 5 articles about Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%