2-(5-amino-2-(furan-2-yl)-7H-pyrazole[4,3-e][1,2,4]triazole[1,5-c]pyrimidine-7-yl)ethyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: 2-(5-amino-2-(furan-2-yl)-7H-pyrazole[4,3-e][1,2,4]triazole[1,5-c]pyrimidine-7-yl)ethyl 4-methylbenzenesulfonate
• CAS No.: 377729-82-3
• Molecular Formula: C₁₉H₁₇N₇O₄S
• Molecular Weight: 439.454

Synonyms:2-(5-amino-2-(furan-2-yl)-7H-pyrazole[4,3-e][1,2,4]triazole[1,5-c]pyrimidine-7-yl)ethyl 4-methylbenzenesulfonate

Chemical Property of 2-(5-amino-2-(furan-2-yl)-7H-pyrazole[4,3-e][1,2,4]triazole[1,5-c]pyrimidine-7-yl)ethyl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-amino-2-(furan-2-yl)-7H-pyrazole[4,3-e][1,2,4]triazole[1,5-c]pyrimidine-7-yl)ethyl 4-methylbenzenesulfonate

There total 5 articles about 2-(5-amino-2-(furan-2-yl)-7H-pyrazole[4,3-e][1,2,4]triazole[1,5-c]pyrimidine-7-yl)ethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-furoic acid hydrazide (3326-71-4) → 2-(5-amino-2-(furan-2-yl)-7H-pyrazole[4,3-e][1,2,4]triazole[1,5-c]pyrimidine-7-yl)ethyl 4-methylbenzenesulfonate (377729-82-3)

Guidance literature:

Multi-step reaction with 4 steps

1: N₂H₄

2: N,O-bis(trimethylsilyl)acetamide / Heating

3: NaH / dimethylformamide

With N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; hydrazine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.11.083

Reference yield:

2-amino-4,6-dichloropyrimidine-5-carboxaldehyde (5604-46-6) → 2-(5-amino-2-(furan-2-yl)-7H-pyrazole[4,3-e][1,2,4]triazole[1,5-c]pyrimidine-7-yl)ethyl 4-methylbenzenesulfonate (377729-82-3)

Guidance literature:

Multi-step reaction with 4 steps

1: N₂H₄

2: N,O-bis(trimethylsilyl)acetamide / Heating

3: NaH / dimethylformamide

With N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; hydrazine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.11.083

Reference yield:

furan-2-carboxylic acid N-(2-amino-6-chloro-5-formylpyrimidin-4-yl)-hydrazide (377729-80-1) → 2-(5-amino-2-(furan-2-yl)-7H-pyrazole[4,3-e][1,2,4]triazole[1,5-c]pyrimidine-7-yl)ethyl 4-methylbenzenesulfonate (377729-82-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N₂H₄

2: N,O-bis(trimethylsilyl)acetamide / Heating

3: NaH / dimethylformamide

With N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; hydrazine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.11.083

upstream raw materials:

1,2-bis-tosyloxyethane

2-furan-2-yl-7H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidin-5-yl amine

2-furoic acid hydrazide

2-amino-4,6-dichloropyrimidine-5-carboxaldehyde

Downstream raw materials:

SCH 412348

preladenant

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