Preladenant

Base Information

Chemical Name:Preladenant
CAS No.:377727-87-2
Molecular Formula:C25H29N9O3
Molecular Weight:503.5563
Hs Code.:
European Community (EC) Number:685-286-0
UNII:950O97NUPO
DSSTox Substance ID:DTXSID90191219
Nikkaji Number:J2.743.968C
Wikipedia:Preladenant
Wikidata:Q7240024
NCI Thesaurus Code:C76394
Pharos Ligand ID:WGBM4ATRULZX
Metabolomics Workbench ID:152950
ChEMBL ID:CHEMBL240624
Mol file:377727-87-2.mol

Synonyms:2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidine-5-amine;preladenant;SCH 420814;SCH-420814;SCH420814

Suppliers and Price of Preladenant

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Preladenant
50mg
$ 3520.00

Medical Isotopes, Inc.
Preladenant
25 mg
$ 2800.00

Medical Isotopes, Inc.
Preladenant
50 mg
$ 4200.00

Matrix Scientific
2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)-ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine 95+%
250mg
$ 1134.00

Matrix Scientific
2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)-ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine 95+%
1g
$ 2520.00

J&W Pharmlab
Preladenant 96%
100mg
$ 750.00

J&W Pharmlab
Preladenant 96%
250mg
$ 400.00

DC Chemicals
Preladenant(SCH420814) >98%
100 mg
$ 450.00

DC Chemicals
Preladenant(SCH420814) >98%
250 mg
$ 800.00

Crysdot
Preladenant 98+%
100mg
$ 797.00

Total 34 raw suppliers

Chemical Property of Preladenant

Chemical Property:

PKA:6.42±0.40(Predicted)
PSA：125.00000
Density:1.47±0.1 g/cm3(Predicted)
LogP:2.74770
Storage Temp.:-20°
Solubility.:Soluble in DMSO (up to 5 mg/ml with warming).
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:9
Exact Mass:503.23933582
Heavy Atom Count:37
Complexity:722

Purity/Quality:

99%, ^*data from raw suppliers

Preladenant ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COCCOC1=CC=C(C=C1)N2CCN(CC2)CCN3C4=C(C=N3)C5=NC(=NN5C(=N4)N)C6=CC=CO6
Recent ClinicalTrials:Follow Up Safety Study of SCH 420814 in Subjects With Parkinson's Disease (P05175)
Recent EU Clinical Trials:A Phase 3, 12-Week, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Preladenant in Subjects with Moderate to Severe Parkinson’s Disease. (Phase 3; Protocol No. P07037)
Description Preladenant is an orally bioavailable antagonist of the adenosine A2A receptor (Kis = 1.1 and 2.5 nM for human and rat receptors, respectively). It is selective for A2A receptors over A1, A2B, and A3 receptors (Kis = >1,000, >1,700, and >1,000 nM, respectively) as well as a panel of 59 receptors, enzymes, and ion channels. Preladenant inhibits adenylate cyclase activity (Kbs = 1.3 and 0.7 nM for human and rat receptors, respectively) induced by the A2A receptor agonist CGS 21680 . It inhibits catalepsy induced by haloperidol in rats by 77 and 70% after 1 and 4 hours, respectively, when administered at a dose of 1 mg/kg. Preladenant also increases the efficacy of L-DOPA when used in combination with eltoprazine in a 6-OHDA rat lesion model of Parkinson’s disease dyskinesia.
Uses A potent and selective antagonist at the adenosine A2A receptor. It is being researched as a potential treatment for Parkinson's disease. A potent and selective antagonist at the adenosine A2A receptor. It is being researched as a potential treatment for Parkinson''s disease.

Technology Process of Preladenant

There total 22 articles about Preladenant which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: methoxyphenol cyanate

: 850648-62-3
C₂₄H₃₀N₈O₃*ClH

: 377727-87-2
preladenant

Guidance literature:: With potassium hydrogencarbonate; In water; acetonitrile; at 53 - 58 ℃; for 1h;

Reference yield: 83.0%

: 1401067-78-4
4-(2-(furan-2-ylmethylene)hydrazinyl)-1-(2-(4-(4-(2-methoxy-ethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

: 377727-87-2
preladenant

Guidance literature:: 4-(2-(furan-2-ylmethylene)hydrazinyl)-1-(2-(4-(4-(2-methoxy-ethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine; With bromine; sodium acetate; acetic acid; at 20 ℃;

With sodium hydroxide; In water; Product distribution / selectivity; Cooling with ice;