4-{4-[7-(4-cyano-2-fluoro-3-methoxy-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-phenyl}-2,2,N-trimethyl-butyramide

Base Information

Chemical Name:4-{4-[7-(4-cyano-2-fluoro-3-methoxy-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-phenyl}-2,2,N-trimethyl-butyramide
CAS No.:1398045-45-8
Molecular Formula:C₂₇H₂₉FN₄O₃S
Molecular Weight:508.617
Hs Code.:

Synonyms:4-{4-[7-(4-cyano-2-fluoro-3-methoxy-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-phenyl}-2,2,N-trimethyl-butyramide

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Chemical Property of 4-{4-[7-(4-cyano-2-fluoro-3-methoxy-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-phenyl}-2,2,N-trimethyl-butyramide

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Technology Process of 4-{4-[7-(4-cyano-2-fluoro-3-methoxy-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-phenyl}-2,2,N-trimethyl-butyramide

There total 8 articles about 4-{4-[7-(4-cyano-2-fluoro-3-methoxy-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-phenyl}-2,2,N-trimethyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1272719-23-9
C₉H₅FN₂OS

: 1398047-59-0
4-(4-(1-cyanocyclobutylamino)phenyl)-N,2,2-trimethylbutanamide

: 1398045-45-8
4-{4-[7-(4-cyano-2-fluoro-3-methoxy-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-phenyl}-2,2,N-trimethyl-butyramide

Guidance literature:: C₉H₅FN₂OS; 4-(4-(1-cyanocyclobutylamino)phenyl)-N,2,2-trimethylbutanamide; In N,N-dimethyl-formamide; at 20 ℃;

With hydrogenchloride; methanol; In N,N-dimethyl-formamide; for 2h; Reflux;

Reference yield:

: 1398047-50-1
C₁₈H₂₈N₂O₃

: 1398045-45-8
4-{4-[7-(4-cyano-2-fluoro-3-methoxy-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-phenyl}-2,2,N-trimethyl-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethyl acetate / 2 h

1.2: 1 h / 0 - 20 °C

2.1: zinc(II) chloride / 1,4-dioxane / 3 h / 20 °C

3.1: N,N-dimethyl-formamide / 20 °C

3.2: 2 h / Reflux

With hydrogenchloride; zinc(II) chloride; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 137654-20-7
2-fluoro-3-methoxybenzoic acid

: 1398045-45-8
4-{4-[7-(4-cyano-2-fluoro-3-methoxy-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-phenyl}-2,2,N-trimethyl-butyramide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 20 °C

1.2: 2 h / Reflux

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 20 °C

4.1: 1 h / 20 °C

4.2: pH 7 / Cooling with ice

5.1: N,N-dimethyl-formamide / 145 °C / Inert atmosphere

5.2: pH 7 / Cooling with ice

6.1: hydrogenchloride / ethanol; water / 1 h / Reflux

6.2: pH 7 - 8

7.1: tetrahydrofuran / 1 h / 20 °C

8.1: N,N-dimethyl-formamide / 20 °C

8.2: 2 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;