137654-20-7

Basic information

• Product Name: 2-FLUORO-3-METHOXYBENZOIC ACID
• Synonyms: 2-FLUORO-3-METHOXYBENZOIC ACID;2-Fluoro-3-methoxybenzoic acid 98%;2-Fluoro-3-methoxybenzoicacid98%;3-Carboxy-2-fluoroanisole;2-Fluoro-3-Methoxybenzoic acd;2-Fluoro-3-Methoxybenzoic Acid(WX612106)
• CAS NO: 137654-20-7
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.14
• EINECS: 1592732-453-0
• Product Categories: blocks;Carboxes;FluoroCompounds;Benzoic acid;Fluorine series
• Mol File: 137654-20-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 157-160°C
• Boiling Point: 296.6 °C at 760 mmHg
• Flash Point: 133.2 °C
• Appearance: /
• Density: 1.307 g/cm³
• Vapor Pressure: 0.000641mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.15±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-3-METHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-METHOXYBENZOIC ACID(137654-20-7)
• EPA Substance Registry System: 2-FLUORO-3-METHOXYBENZOIC ACID(137654-20-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 137654-20-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-3-methoxybenzoic acid is used as an intermediate in the synthesis of various pharmaceutical compounds for its unique chemical properties, contributing to the development of new drugs with improved therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Fluoro-3-methoxybenzoic acid serves as a key intermediate in the production of agrochemicals, such as pesticides and herbicides, enhancing their effectiveness in controlling pests and weeds.
Used in Research and Development:
2-Fluoro-3-methoxybenzoic acid is employed in research and development processes to explore its potential applications in various fields, including the synthesis of new organic compounds and the investigation of its chemical properties and reactivity.
It is crucial to handle 2-Fluoro-3-methoxybenzoic acid with care due to its potential hazards, such as skin and eye irritation, ensuring safety in its applications across different industries.

InChI:InChI=1/C8H7FO3/c1-12-6-4-2-3-5(7(6)9)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 321-28-8 1-fluoro-2-methoxybenzene 
• 103438-88-6 2-fluoro-3-methoxybenzaldehyde 
• 124-38-9 carbon dioxide 

Downstream Products

• 935534-45-5 6-bromo-2-fluoro-3-methoxy-benzoic acid 
• 801282-00-8 2-fluoro-3-methoxyaniline 
• 801281-99-2 tert-butyl N-(2-fluoro-3-methoxyphenyl)carbamate 
• 1007455-31-3 7-fluoro-6-methoxylisoindolin-1-one 
• 103438-88-6 2-fluoro-3-methoxybenzaldehyde 

Relevant articles and documents

Palladium-catalyzed aryl-aryl cross-coupling reaction using ortho-substituted arylindium reagents

(Chemical Equation Presented) A range of biaryl compounds (aryl-aryl, aryl-heteroaryl, and heteroaryl-heteroaryl) can be efficiently prepared by a palladium-catalyzed cross-coupling reaction between ortho-substituted triarylindium reagents and aryl halide

Expedient Pd-Catalyzed α-Arylation towards Dibenzoxepinones: Pivotal Manske's Ketone for the Formal Synthesis of Cularine Alkaloids

The general synthesis of diversely substituted dibenzoxepinones by a combined Pd-catalyzed α-arylation and SNAr strategy is reported and applied to the synthesis of Manske's ketone, a key intermediate en route to the total synthesis of cularine alkaloids. In the course of this work, an unanticipated ring contraction reaction to a xanthone was observed and serves as a caveat for the conditions of the widely used α-arylation reaction.

Method for synthesizing ethyl 2-bromo-2-(2-fluoro-3-methoxyphenyl) acetate by carbon dioxide method

The invention discloses a method for synthesizing ethyl 2-bromo-2-(2-fluoro-3-methoxyphenyl) acetate by a carbon dioxide method. A synthetic route is as shown in specification. The preparation methodof the compound comprises preparation of a compound of f

Synthesis of methyl-, fluoro-, and chloro-substituted 6-hydroxyisoindolin-1-ones

The synthesis of a series of methyl-, fluoro-, and chloro-substituted 6-hydroxyisoindolin-1-ones is described.

ISOINDOLE DERIVATIVES

This invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, a process of making these compounds, pharmaceutical compositions containing one or more of these compounds or their salts, and their use for the treatment of schizophrenia, bipolar disorder, or other central nervous system disorders.

PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

A compound of formula (I), pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof for the treatment of asthma, allergic rhinitis, COPD, inflammatory bowel disease, irritable bowel syndrome, osteoarthritis, osteoporosis, rheumatoid

Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries

A method for encoding solid-phase split/mix combinatorial libraries using the chemical shift of synthetic fluoroarenes ('F-codes') has been developed. They have wide chemical shift dispersion and are detectable at the sub-μmol level. 19F NMR is

Benzopyranopyrazolyl derivatives for the treatment of inflammation

A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I STR1 wherein A is --(CH2)m --X--(CH2)n --; wherein X is S(O)p or O; wherein m is 0 or 1; wherein n is 0 or 1; wherein p is 0 or 1; wherein B is selected from phenyl and five and six membered heteroaryl; wherein R1 is selected from lower haloalkyl, cyano, formyl, lower alkoxycarbonyl, lower alkoxy, lower N-alkylaminocarbonyl, N-phenylaminocarbonyl, lower N,N-dialkylaminocarbonyl and lower N-alkyl-N-phenylaminocarbonyl; wherein R2 is phenyl substituted at a substitutable position with a radical selected from lower alkylsulfonyl and sulfamyl; and wherein R4 is one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, amino, lower N-alkylamino, lower N,N-dialkylamino, lower hydroxyalkyl and lower haloalkoxy; or a pharmaceutically-acceptable salt thereof.