6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

Base Information

Chemical Name:6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane
CAS No.:914618-40-9
Molecular Formula:C₁₉H₂₈O₃
Molecular Weight:304.43
Hs Code.:

Synonyms:6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

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Chemical Property of 6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

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Technology Process of 6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

There total 4 articles about 6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 914618-36-3
2-(7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)ethanol

: 100-39-0
benzyl bromide

: 914618-40-9
6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/ejoc.200600361

Reference yield:

: 914618-35-2
methyl (7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)acetate

: 914618-40-9
6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / 20 °C

2: 60 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran;
DOI:10.1002/ejoc.200600361

Reference yield:

: 1193-18-6
3-methylcyclohexen-2-one

: 914618-40-9
6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(I) bromide / tetrahydrofuran; diethyl ether / 2 h / 0 °C

1.2: 70 percent / DMPU / tetrahydrofuran; diethyl ether / 0 - 20 °C

2.1: 99 percent / para-toluenesulfonic acid / toluene / 5 h / Heating

3.1: 99 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / 20 °C

4.1: 60 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; copper(I) bromide; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1002/ejoc.200600361