6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

Base Information

• Chemical Name: 6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane
• CAS No.: 914618-40-9
• Molecular Formula: C₁₉H₂₈O₃
• Molecular Weight: 304.43
• Mol file: 914618-40-9.mol

Synonyms:6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

Chemical Property of 6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane

There total 4 articles about 6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-(7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)ethanol (914618-36-3) + benzyl bromide (100-39-0) → 6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane (914618-40-9)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/ejoc.200600361

Reference yield:

methyl (7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)acetate (914618-35-2) → 6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane (914618-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / 20 °C

2: 60 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran;

DOI:10.1002/ejoc.200600361

Reference yield:

3-methylcyclohexen-2-one (1193-18-6) → 6-[2-(benzyloxy)ethyl]-7,7-dimethyl-1,4-dioxaspiro[4.5]decane (914618-40-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: copper(I) bromide / tetrahydrofuran; diethyl ether / 2 h / 0 °C

1.2: 70 percent / DMPU / tetrahydrofuran; diethyl ether / 0 - 20 °C

2.1: 99 percent / para-toluenesulfonic acid / toluene / 5 h / Heating

3.1: 99 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / 20 °C

4.1: 60 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; copper(I) bromide; In tetrahydrofuran; diethyl ether; toluene;

DOI:10.1002/ejoc.200600361

upstream raw materials:

2-(7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)ethanol

benzyl bromide

methyl (7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)acetate

3-methylcyclohexen-2-one