Chemical Property of 2-Chloro-5-nitro-N-4-pyridinylbenzamide
Chemical Property:
- Vapor Pressure:4.98E-06mmHg at 25°C
- Refractive Index:1.684
- Boiling Point:381.7°Cat760mmHg
- Flash Point:184.6°C
- PSA：87.81000
- Density:1.498g/cm3
- LogP:3.49170
- Storage Temp.:Store at RT
- Sensitive.:Light Sensitive
- Solubility.:DMSO: >10mg/mL
- Water Solubility.:Soluble in DMSO at 10mg/ml. Insoluble in water.
- XLogP3:2.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:277.0254188
- Heavy Atom Count:19
- Complexity:342
- Purity/Quality:
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99%, *data from raw suppliers
T 0070907 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-36
- Safety Statements:
26
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1=CC(=C(C=C1[N+](=O)[O-])C(=O)NC2=CC=NC=C2)Cl
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Description
The peroxisome proliferator-activated receptor-γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs). TZDs are a group of structurally related synthetic PPARγ receptor agonists with antidiabetic actions in vivo. There are many PPARγ agonists, including 15-deoxy-Δ12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. T0070907 is a potent and selective antagonist of the human PPARγ with an apparent IC50 of 1 nM for the binding inhibition of rosiglitazone, a reference TZD. T0070907 covalently binds to Cys313 of PPARγ, inducing conformational changes that block the recruitment of transcriptional cofactors to the PPARγ/RXR heterodimer.
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Uses
A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPAR with a Ki of 1 nM. Displays >800-fold greater selectivity for PPAR over PPARa and PPARd (Ki = 0.85 and 1.8 , T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.
