2-{2-[(allylmethylamino)methyl]-4-aminophenoxy}-1-pyrrolidin-1-ylethanone

Base Information

Chemical Name:2-{2-[(allylmethylamino)methyl]-4-aminophenoxy}-1-pyrrolidin-1-ylethanone
CAS No.:1354567-45-5
Molecular Formula:C₁₇H₂₅N₃O₂
Molecular Weight:303.404
Hs Code.:

Synonyms:2-{2-[(allylmethylamino)methyl]-4-aminophenoxy}-1-pyrrolidin-1-ylethanone

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Chemical Property of 2-{2-[(allylmethylamino)methyl]-4-aminophenoxy}-1-pyrrolidin-1-ylethanone

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Technology Process of 2-{2-[(allylmethylamino)methyl]-4-aminophenoxy}-1-pyrrolidin-1-ylethanone

There total 5 articles about 2-{2-[(allylmethylamino)methyl]-4-aminophenoxy}-1-pyrrolidin-1-ylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1354567-02-4
2-{2-[(allylmethylamino)methyl]-4-nitrophenoxy}-1-pyrrolidin-1-ylethanone

: 1354567-45-5
2-{2-[(allylmethylamino)methyl]-4-aminophenoxy}-1-pyrrolidin-1-ylethanone

Guidance literature:: With iron; ammonium chloride; In ethanol; water; Reflux;
DOI:10.1021/jm201112g

Reference yield:

: 1156670-01-7
5-nitro-2-(2-oxo-2-pyrrolidin-1-ylethoxy)benzaldehyde

: 1354567-45-5
2-{2-[(allylmethylamino)methyl]-4-aminophenoxy}-1-pyrrolidin-1-ylethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

2: iron; ammonium chloride / ethanol; water / Reflux

With sodium tris(acetoxy)borohydride; iron; ammonium chloride; In ethanol; dichloromethane; water;
DOI:10.1021/jm201112g

Reference yield:

: 24582-00-1
(2-formyl-4-nitrophenoxy)acetic acid methyl ester

: 1354567-45-5
2-{2-[(allylmethylamino)methyl]-4-aminophenoxy}-1-pyrrolidin-1-ylethanone

Guidance literature:: Multi-step reaction with 4 steps

1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

4: iron; ammonium chloride / ethanol; water / Reflux

With water; sodium tris(acetoxy)borohydride; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm201112g