2-{2-[(allylmethylamino)methyl]-4-nitrophenoxy}-1-pyrrolidin-1-ylethanone

Base Information

Chemical Name:2-{2-[(allylmethylamino)methyl]-4-nitrophenoxy}-1-pyrrolidin-1-ylethanone
CAS No.:1354567-02-4
Molecular Formula:C₁₇H₂₃N₃O₄
Molecular Weight:333.387
Hs Code.:

Synonyms:2-{2-[(allylmethylamino)methyl]-4-nitrophenoxy}-1-pyrrolidin-1-ylethanone

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Chemical Property of 2-{2-[(allylmethylamino)methyl]-4-nitrophenoxy}-1-pyrrolidin-1-ylethanone

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Technology Process of 2-{2-[(allylmethylamino)methyl]-4-nitrophenoxy}-1-pyrrolidin-1-ylethanone

There total 4 articles about 2-{2-[(allylmethylamino)methyl]-4-nitrophenoxy}-1-pyrrolidin-1-ylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 627-37-2
N-methyl-N-allylamine

: 1156670-01-7
5-nitro-2-(2-oxo-2-pyrrolidin-1-ylethoxy)benzaldehyde

: 1354567-02-4
2-{2-[(allylmethylamino)methyl]-4-nitrophenoxy}-1-pyrrolidin-1-ylethanone

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;
DOI:10.1021/jm201112g

Reference yield:

: 24582-00-1
(2-formyl-4-nitrophenoxy)acetic acid methyl ester

: 1354567-02-4
2-{2-[(allylmethylamino)methyl]-4-nitrophenoxy}-1-pyrrolidin-1-ylethanone

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

With water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm201112g

Reference yield:

: 6965-69-1
2-(2-formyl-4-nitrophenoxy)acetic acid

: 1354567-02-4
2-{2-[(allylmethylamino)methyl]-4-nitrophenoxy}-1-pyrrolidin-1-ylethanone

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jm201112g