Technology Process of 5-({4-[2-(4-chlorophenyl)-1-(1,3,4-oxadiazol-2-yl)ethenyl]phenoxy}methyl)-1H-indazole
There total 9 articles about 5-({4-[2-(4-chlorophenyl)-1-(1,3,4-oxadiazol-2-yl)ethenyl]phenoxy}methyl)-1H-indazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 5-({4-[2-(4-chlorophenyl)-1-(1,3,4-oxadiazol-2-yl)ethenyl]phenoxy}methyl)-1H-indazole-1-carboxylate;
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 4h;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine / 3 h / Reflux
1.2: 0.5 h / Reflux
2.1: sulfuric acid / 16 h / Reflux
3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 0.25 h / 22 - 26 °C
3.2: Acidic conditions
4.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
4.2: 1 h / 0 °C
5.1: toluene-4-sulfonic acid / 2 h / 90 - 100 °C
6.1: sodium hydroxide; water / ethanol / 0.25 h / 22 - 26 °C
6.2: Acidic conditions
7.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 22 - 26 °C
7.2: 16 h / 22 - 26 °C
8.1: trifluoroacetic acid / dichloromethane / 4 h / 0 °C
With
sulfuric acid; water; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane;
1.1: Perkin Reaction / 7.1: Mitsunobu reaction / 7.2: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine / 3 h / Reflux
1.2: 0.5 h / Reflux
2.1: sulfuric acid / 16 h / Reflux
3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 0.25 h / 22 - 26 °C
3.2: Acidic conditions
4.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
4.2: 1 h / 0 °C
5.1: toluene-4-sulfonic acid / 2 h / 90 - 100 °C
6.1: sodium hydroxide; water / ethanol / 0.25 h / 22 - 26 °C
6.2: Acidic conditions
7.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 22 - 26 °C
7.2: 16 h / 22 - 26 °C
8.1: trifluoroacetic acid / dichloromethane / 4 h / 0 °C
With
sulfuric acid; water; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane;
1.1: Perkin Reaction / 7.1: Mitsunobu reaction / 7.2: Mitsunobu reaction;
![tert-butyl 5-({4-[2-(4-chlorophenyl)-1-(1,3,4-oxadiazol-2-yl)ethenyl]phenoxy}methyl)-1H-indazole-1-carboxylate](/Databaselist/images/loading.webp)
