Technology Process of 6-fluoro-2-[2-[(2-methoxyethoxy)methoxy]biphenyl-3-yl]-1H-indole-5-carbonitrile
There total 9 articles about 6-fluoro-2-[2-[(2-methoxyethoxy)methoxy]biphenyl-3-yl]-1H-indole-5-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 100 percent / H2 / 10percent Pd/C / methanol / 8 h / 760.05 Torr
2.1: 33 percent / NIS; AcOH / 2 h / 20 °C
3.1: DIEA; DMAP / tetrahydrofuran / 3 h
3.2: 47 percent / 50percent aq. NaOH / ethanol; tetrahydrofuran / 2 h
4.1: Et3N; Pd(PPh3)2Cl2; CuI / dimethylformamide / 2 h
5.1: tetrabutylammonium fluoride / tetrahydrofuran / 5 h / Heating
With
dmap; bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine;
10percent Pd/C;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm010244+
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 52 percent / aq. CrO3; H2SO4; AcOH / 20 - 100 °C
2.1: (COCl)2; DMF / tetrahydrofuran / 3 h / 0 - 20 °C
3.1: 15.5 g / NH3 gas / tetrahydrofuran / 2.5 h / 0 °C
4.1: 14.7 g / Et3N; (CF3CO)2O / tetrahydrofuran / 16 h / 20 °C
5.1: 100 percent / H2 / 10percent Pd/C / methanol / 8 h / 760.05 Torr
6.1: 33 percent / NIS; AcOH / 2 h / 20 °C
7.1: DIEA; DMAP / tetrahydrofuran / 3 h
7.2: 47 percent / 50percent aq. NaOH / ethanol; tetrahydrofuran / 2 h
8.1: Et3N; Pd(PPh3)2Cl2; CuI / dimethylformamide / 2 h
9.1: tetrabutylammonium fluoride / tetrahydrofuran / 5 h / Heating
With
chromium(VI) oxide; dmap; bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; oxalyl dichloride; sulfuric acid; tetrabutyl ammonium fluoride; ammonia; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride;
10percent Pd/C;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm010244+
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: (COCl)2; DMF / tetrahydrofuran / 3 h / 0 - 20 °C
2.1: 15.5 g / NH3 gas / tetrahydrofuran / 2.5 h / 0 °C
3.1: 14.7 g / Et3N; (CF3CO)2O / tetrahydrofuran / 16 h / 20 °C
4.1: 100 percent / H2 / 10percent Pd/C / methanol / 8 h / 760.05 Torr
5.1: 33 percent / NIS; AcOH / 2 h / 20 °C
6.1: DIEA; DMAP / tetrahydrofuran / 3 h
6.2: 47 percent / 50percent aq. NaOH / ethanol; tetrahydrofuran / 2 h
7.1: Et3N; Pd(PPh3)2Cl2; CuI / dimethylformamide / 2 h
8.1: tetrabutylammonium fluoride / tetrahydrofuran / 5 h / Heating
With
dmap; bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; oxalyl dichloride; tetrabutyl ammonium fluoride; ammonia; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride;
10percent Pd/C;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm010244+
