(4-Methoxy-phenyl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (4-Methoxy-phenyl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester
• CAS No.: 176211-96-4
• Molecular Formula: C₂₀H₂₅NO₃
• Molecular Weight: 327.423
• Mol file: 176211-96-4.mol

Synonyms:(4-Methoxy-phenyl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester

Chemical Property of (4-Methoxy-phenyl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (4-Methoxy-phenyl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester

There total 1 articles about (4-Methoxy-phenyl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(t-butoxycarbonyl)-N-(4-methoxyphenyl)-benzylamine + methyl trifluoromethanesulfonate (333-27-7) → (4-Methoxy-phenyl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester (176211-96-4)

Guidance literature:

With n-butyllithium; (-)-sparteine; Multistep reaction; 1.) toluene, -78 deg C, 10 h, 2.) toluene;

DOI:10.1021/ja9538804

Reference yield:

(4-Methoxy-phenyl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester (176211-96-4) → (R)-2-(4-Methoxy-phenylamino)-2-phenyl-propionic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi, TMEDA / 1.) toluene-d8, -78 deg C, 2.) toluene

2: SOCl₂ / methanol / 2 h / Heating

With n-butyllithium; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; In methanol;

DOI:10.1021/ja972225o

Reference yield:

(4-Methoxy-phenyl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester (176211-96-4) → (S)-2-(4-Methoxy-phenylamino)-2-phenyl-propionic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi, TMEDA / 1.) toluene-d8, -78 deg C, 8 h, 2.) toluene

2: aq. CF₃COOH / CH₂Cl₂ / Ambient temperature

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja972225o

upstream raw materials:

methyl trifluoromethanesulfonate

Downstream raw materials:

(4-Methoxy-phenyl)-((S)-1-methyl-1-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

(R)-(1-phenylethyl)carbamic acid tert-butyl ester

(S)-tert-butyl 1-phenylethylcarbamate

(R)-2-[tert-Butoxycarbonyl-(4-methoxy-phenyl)-amino]-2-phenyl-propionic acid