Technology Process of N-d5-phenyl isobutyrylacetamide
There total 1 articles about N-d5-phenyl isobutyrylacetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 2 steps
1: 15.26 g / β-alanine; glacial acetic acid / hexane / 25 h / Heating
2: 4.7 g / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / 21 h / 75 - 80 °C
With
3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; acetic acid; triethylamine; 3-amino propanoic acid;
In
ethanol; hexane;
1: Condensation / 2: Addition;
DOI:10.1002/(SICI)1099-1344(20000315)43:3<261::AID-JLCR312>3.0.CO;2-T
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 15.26 g / β-alanine; glacial acetic acid / hexane / 25 h / Heating
2: 4.7 g / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / 21 h / 75 - 80 °C
3: 4.07 g / pivalic acid / tetrahydrofuran; toluene; heptane / 24 h / Heating
4: HCl / tetrahydrofuran; H2O / 23 h / 20 °C
5: sodium hydroxide / H2O; tetrahydrofuran / 64 h / 20 °C
6: 2.0 g / trifluoroacetic acid / ethyl acetate / 16 h / 50 °C
With
hydrogenchloride; sodium hydroxide; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; acetic acid; triethylamine; trifluoroacetic acid; 3-amino propanoic acid; Trimethylacetic acid;
In
tetrahydrofuran; ethanol; hexane; n-heptane; water; ethyl acetate; toluene;
1: Condensation / 2: Addition / 3: Cycloaddition / 4: Hydrolysis / 5: Hydrolysis / 6: Cyclization;
DOI:10.1002/(SICI)1099-1344(20000315)43:3<261::AID-JLCR312>3.0.CO;2-T
