(1R,2R)-2-pyridin-2-ylcyclopropanecarboxylic acid ((2S,3S)-2-amino-3-methylpentyl)-(4-(cyclobutylmethoxy)phenyl)amide

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Chemical Name:(1R,2R)-2-pyridin-2-ylcyclopropanecarboxylic acid ((2S,3S)-2-amino-3-methylpentyl)-(4-(cyclobutylmethoxy)phenyl)amide
CAS No.:1287205-60-0
Molecular Formula:C₂₆H₃₅N₃O₂
Molecular Weight:421.583
Hs Code.:

Synonyms:(1R,2R)-2-pyridin-2-ylcyclopropanecarboxylic acid ((2S,3S)-2-amino-3-methylpentyl)-(4-(cyclobutylmethoxy)phenyl)amide

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Chemical Property of (1R,2R)-2-pyridin-2-ylcyclopropanecarboxylic acid ((2S,3S)-2-amino-3-methylpentyl)-(4-(cyclobutylmethoxy)phenyl)amide

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Technology Process of (1R,2R)-2-pyridin-2-ylcyclopropanecarboxylic acid ((2S,3S)-2-amino-3-methylpentyl)-(4-(cyclobutylmethoxy)phenyl)amide

There total 6 articles about (1R,2R)-2-pyridin-2-ylcyclopropanecarboxylic acid ((2S,3S)-2-amino-3-methylpentyl)-(4-(cyclobutylmethoxy)phenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 17247-58-4
(Bromomethyl)cyclobutane

: 1287206-03-4
tert-butyl (2S,3S)-1-((1R,2R)-N-(4-hydroxyphenyl)-2-(pyridin-2-yl)cyclopropanecarboxamido)-3-methylpentan-2-ylcarbamate

: 1287205-60-0
(1R,2R)-2-pyridin-2-ylcyclopropanecarboxylic acid ((2S,3S)-2-amino-3-methylpentyl)-(4-(cyclobutylmethoxy)phenyl)amide

Guidance literature:: (Bromomethyl)cyclobutane; tert-butyl (2S,3S)-1-((1R,2R)-N-(4-hydroxyphenyl)-2-(pyridin-2-yl)cyclopropanecarboxamido)-3-methylpentan-2-ylcarbamate; With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

With acetyl chloride; In methanol; at 0 - 20 ℃;

Reference yield:

: 141321-52-0,141321-53-1,141321-50-8,106946-74-1,545433-88-3
N-(tert-butoxycarbonyl)-L-isoleucinol

: 1287205-60-0
(1R,2R)-2-pyridin-2-ylcyclopropanecarboxylic acid ((2S,3S)-2-amino-3-methylpentyl)-(4-(cyclobutylmethoxy)phenyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 0 °C

2.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 35 °C

3.2: 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C

5.2: 0 - 20 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: (1,2-trans)-2-pyridin-2'-yl-cyclopropanecarboxylic acid

: 1287205-60-0
(1R,2R)-2-pyridin-2-ylcyclopropanecarboxylic acid ((2S,3S)-2-amino-3-methylpentyl)-(4-(cyclobutylmethoxy)phenyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 35 °C

1.2: 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C

3.2: 0 - 20 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;