1-(1-(cyclohex-1-en-1-yl)ethyl)-4-nitrobenzene

Base Information

• Chemical Name: 1-(1-(cyclohex-1-en-1-yl)ethyl)-4-nitrobenzene
• CAS No.: 1452823-91-4
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 1452823-91-4.mol

Synonyms:1-(1-(cyclohex-1-en-1-yl)ethyl)-4-nitrobenzene

Chemical Property of 1-(1-(cyclohex-1-en-1-yl)ethyl)-4-nitrobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-(cyclohex-1-en-1-yl)ethyl)-4-nitrobenzene

There total 4 articles about 1-(1-(cyclohex-1-en-1-yl)ethyl)-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

cyclohex-1-en-1-yl trifluoromethane sulfonate (28075-50-5) + potassium 2-(4-nitrophenyl)propanoate (1316860-02-2) → 1-(1-(cyclohex-1-en-1-yl)ethyl)-4-nitrobenzene (1452823-91-4)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); XPhos; In diethylene glycol dimethyl ether; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201209970

Reference yield:

methyl (4-nitrophenyl)acetate (2945-08-6) → 1-(1-(cyclohex-1-en-1-yl)ethyl)-4-nitrobenzene (1452823-91-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2.1: potassium hydroxide / tetrahydrofuran; methanol; water / 20 °C / Inert atmosphere

2.2: pH 4 - 5 / Inert atmosphere

2.3: 1 h / 20 °C / Inert atmosphere

3.1: bis(η3-allyl-μ-chloropalladium(II)); XPhos / diethylene glycol dimethyl ether / 2 h / 100 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate; potassium hydroxide; XPhos; In tetrahydrofuran; methanol; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide;

DOI:10.1002/anie.201209970

Reference yield:

methyl 2-(4-nitrobenzene)propionate (50415-69-5) → 1-(1-(cyclohex-1-en-1-yl)ethyl)-4-nitrobenzene (1452823-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / tetrahydrofuran; methanol; water / 20 °C / Inert atmosphere

1.2: pH 4 - 5 / Inert atmosphere

1.3: 1 h / 20 °C / Inert atmosphere

2.1: bis(η3-allyl-μ-chloropalladium(II)); XPhos / diethylene glycol dimethyl ether / 2 h / 100 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); potassium hydroxide; XPhos; In tetrahydrofuran; methanol; diethylene glycol dimethyl ether; water;

DOI:10.1002/anie.201209970

upstream raw materials:

cyclohex-1-en-1-yl trifluoromethane sulfonate

potassium 2-(4-nitrophenyl)propanoate

methyl (4-nitrophenyl)acetate

methyl 2-(4-nitrobenzene)propionate