[2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester

Base Information

Chemical Name:[2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester
CAS No.:273720-78-8
Molecular Formula:C₄₁H₅₄N₂O₁₂
Molecular Weight:766.886
Hs Code.:

[2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1<i>H</i>-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid <i>tert</i>-butyl ester

Synonyms:[2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester

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Chemical Property of [2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester

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Technology Process of [2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester

There total 5 articles about [2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 273720-74-4
{2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-1-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-benzyl]-ethyl}-methyl-carbamic acid tert-butyl ester

: 273720-78-8
[2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: With buffer solution; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 25 ℃; for 3h; pH=7;
DOI:10.1002/anie.200503982

Reference yield:

: 273720-77-7
{2-(1-benzyloxymethyl-4-hydroxy-5,7,8-trimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-1-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-benzyl]-ethyl}-methyl-carbamic acid tert-butyl ester

: 273720-78-8
[2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 25 °C

2: 90 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; buffer solution / CH₂Cl₂ / 3 h / 25 °C / pH 7

With buffer solution; Dess-Martin periodane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;
DOI:10.1002/anie.200503982

Reference yield:

: 271578-85-9
(R)-1-Benzyloxymethyl-5,7,8-trimethoxy-6-methyl-1,2,3,4-tetrahydro-isoquinolin-4-ol

: 273720-78-8
[2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; triethylamine / CH₂Cl₂ / 12 h / 25 °C

2: 78 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 25 °C

3: 90 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; buffer solution / CH₂Cl₂ / 3 h / 25 °C / pH 7

With buffer solution; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; Dess-Martin periodane; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;
DOI:10.1002/anie.200503982