(2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide

Base Information

Chemical Name:(2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide
CAS No.:1449329-47-8
Molecular Formula:C₂₅H₂₅Cl₂N₅O₅S
Molecular Weight:578.476
Hs Code.:

(2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide

Synonyms:(2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide

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Chemical Property of (2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide

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Technology Process of (2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide

There total 3 articles about (2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1449329-46-7
3-[(2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-2-(1-cyano-cyclopropylcarbamoyl)-pyrrolidine-1-carbonyl]-3-(5-chloro-pyridin-2-yl)-azetidine-1-carboxylic acid tert-butyl ester

: 1449329-47-8
(2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide

Guidance literature:: 3-[(2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-2-(1-cyano-cyclopropylcarbamoyl)-pyrrolidine-1-carbonyl]-3-(5-chloro-pyridin-2-yl)-azetidine-1-carboxylic acid tert-butyl ester; With formic acid; at 20 ℃; for 20h;

With sodium carbonate; In water; pH=8; Cooling with ice;

Reference yield:

: 1449330-32-8
3-(5-chloro-pyridin-2-yl)-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

: 1449329-47-8
(2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / tetrahydrofuran / 2 h / 22 °C

2.1: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

3.1: formic acid / 20 h / 20 °C

3.2: pH 8 / Cooling with ice

With formic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; acetonitrile;

Reference yield:

: 1480-65-5
2-fluoro-5-chloropyridine

: 1449329-47-8
(2S,4R)-4-(2-chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / toluene / 3.5 h / 0 - 20 °C

2.1: lithium hydroxide / tetrahydrofuran / 2 h / 22 °C

3.1: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

4.1: formic acid / 20 h / 20 °C

4.2: pH 8 / Cooling with ice

With formic acid; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; toluene; acetonitrile;