1480-65-5

Basic information

• Product Name: 5-Chloro-2-fluoropyridine
• Synonyms: 5-CHLORO-2-FLUOROPYRIDINE;3-Chloro-6-fluoropyridine;2-Chloro-5-Fluoroypyridine;5-chloro-2-fluoropyridine-5-chloro-2-fluoropyridine;5-Chloro-2-fluoropyridine ,97%;5-Chloro-2-fluoropyridine 97%;2-FLUORO-5-CHLORO PYRIDINE;2-FLUORO-5-C
• CAS NO: 1480-65-5
• Molecular Formula: C₅H₃ClFN
• Molecular Weight: 131.54
• EINECS: 200-589-5
• Product Categories: blocks;Pyridines;Pyridine;Pyridine series;Boronic Acid;Building Blocks;C5;C5 to C6;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;Fluorine series
• Mol File: 1480-65-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 149℃
• Flash Point: 126
• Appearance: Light yellow liquid
• Density: 1.311
• Vapor Pressure: 3.48mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: 2-8°C
• PKA: -2.71±0.10(Predicted)
• CAS DataBase Reference: 5-Chloro-2-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-fluoropyridine(1480-65-5)
• EPA Substance Registry System: 5-Chloro-2-fluoropyridine(1480-65-5)

Safety Data

• Hazard Codes: Xi,F,T,Xn
• Statements: 10-22-37/38-41-36/37/38
• Safety Statements: 26-39-36
• RIDADR: UN 1993
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 1480-65-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to brown liquid

InChI:InChI=1/C5H3ClFN/c6-4-1-2-5(7)8-3-4/h1-3H

Upstream product

• 40473-01-6 2-Bromo-5-chloro-pyridine 

Downstream Products

• 1112788-71-2 1-(6-fluoropyridin-3-yl)-5-phenylpentan-3-one 
• 1137726-28-3 4-(6-fluoropyridin-3-yl)butyl benzoate 
• 1243333-41-6 (R)-3-(6-fluoropyridin-3-yl)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethylpropanamide 
• 928822-80-4 2-fluoro-5-phenyl-pyridine 
• 1337563-01-5 3-(4-methylbenzene)-6-fluoropyridine 
• 1438894-25-7 3-(6-fluoropyridin-3-yl)-9-phenylcarbazole 
• 1569084-95-2 (2S,4R)-4-(2-chloro-4-methoxybenzenesulfonyl)-1-[1-(5-chloropyridin-2-yl)cyclopropanecarbonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide 
• 1256793-26-6 1-(5-chloropyridin-2-yl)cyclopropanecarboxylic acid 
• 1609468-06-5 benzyl 3-(5-acetamido-3-{4-[(5-chloropyridin-2-yl)oxy]phenyl}-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1609468-07-6 5-amino-3-(4-((5-chloropyridin-2-yl)oxy)phenyl )-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide 
• 1609466-84-3 5-amino-3-(4-((5-chloropyridin-2-yl)oxy)phenyl)-1-(1-cyanopiperidin-3-yl)-1H-pyrazole-4-carboxamide 
• 1609466-85-4 (S)-5-amino-3-(4-((5-chloropyridin-2-yl)oxy)phenyl)-1-(1-cyanopiperidin-3-yl)-1H-pyrazole-4-carboxamide 
• 1609466-86-5 (R)-5-amino-3-(4-((5-chloropyridin-2-yl)oxy)phenyl)-1-(1-cyanopiperidin-3-yl)-1H-pyrazole-4-carboxamide 
• 1609468-32-7 (R)-benzyl 3-(5-acetamido-3-(4-((5-chloropyridin-2-yl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate 

Relevant articles and documents

Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination

Nucleophilic aromatic fluorination (SNAr) is among the most common methods for the formation of C(sp2)-F bonds. Despite many recent advances, a long-standing limitation of these transformations is the requirement for rigorously dry, aprotic conditions to maintain the nucleophilicity of fluoride and suppress the generation of side products. This report addresses this challenge by leveraging tetramethylammonium fluoride alcohol adducts (Me4NF·ROH) as fluoride sources for SNAr fluorination. Through systematic tuning of the alcohol substituent (R), tetramethylammonium fluoride tert-amyl alcohol (Me4NF·t-AmylOH) was identified as an inexpensive, practical, and bench-stable reagent for SNAr fluorination under mild and convenient conditions (80 °C in DMSO, without the requirement for drying of reagents or solvent). A substrate scope of more than 50 (hetero) aryl halides and nitroarene electrophiles is demonstrated.