(R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanol

Base Information

• Chemical Name: (R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanol
• CAS No.: 118958-57-9
• Molecular Formula: C₂₈H₃₆O₄Si
• Molecular Weight: 464.677
• Mol file: 118958-57-9.mol

Synonyms:(R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanol

Chemical Property of (R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanol

There total 4 articles about (R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl (R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanoate (118958-79-5) → (R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanol (118958-57-9)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; toluene; at -30 - -20 ℃; for 2.5h;

DOI:10.1002/hlca.19880710204

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → (R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanol (118958-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 42.5 g / 4-(dimethylamino)pyridine / dimethylformamide / 1.5 h / Ambient temperature

2: 93 percent / DIBAH / toluene; diethyl ether / 2.5 h / -30 - -20 °C

With dmap; diisobutylaluminium hydride; In diethyl ether; N,N-dimethyl-formamide; toluene;

DOI:10.1002/hlca.19880710204

Reference yield:

(R)-2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethanoic acid (118958-66-0) → (R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanol (118958-57-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 92.6 percent / K₂CO₃ / acetone / 1 h / Heating

2: 42.5 g / 4-(dimethylamino)pyridine / dimethylformamide / 1.5 h / Ambient temperature

3: 93 percent / DIBAH / toluene; diethyl ether / 2.5 h / -30 - -20 °C

With dmap; diisobutylaluminium hydride; potassium carbonate; In diethyl ether; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1002/hlca.19880710204

upstream raw materials:

methyl (R)-2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethanoate

tert-butyldimethylsilyl chloride

(R)-2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethanoic acid

methyl (R)-2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethanoate

Downstream raw materials:

(R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>heptanoic acid

tert-butyl (R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethyl>amino>heptanoate

tert-butyl (R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>heptanoate

2-<3,4-bis(benzyloxy)phenyl>-2-<(tert-butyl)dimethylsilyloxy>ethyl methanesulfonate