2-mercapto-N-[5-(5-methyl-3-phenylisoxazol-4-ylmethoxy)pentyl]propionamide

Base Information

Chemical Name:2-mercapto-N-[5-(5-methyl-3-phenylisoxazol-4-ylmethoxy)pentyl]propionamide
CAS No.:1368806-91-0
Molecular Formula:C₁₉H₂₆N₂O₃S
Molecular Weight:362.493
Hs Code.:

Synonyms:2-mercapto-N-[5-(5-methyl-3-phenylisoxazol-4-ylmethoxy)pentyl]propionamide

Suppliers and Price of 2-mercapto-N-[5-(5-methyl-3-phenylisoxazol-4-ylmethoxy)pentyl]propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-mercapto-N-[5-(5-methyl-3-phenylisoxazol-4-ylmethoxy)pentyl]propionamide

Chemical Property:

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Technology Process of 2-mercapto-N-[5-(5-methyl-3-phenylisoxazol-4-ylmethoxy)pentyl]propionamide

There total 9 articles about 2-mercapto-N-[5-(5-methyl-3-phenylisoxazol-4-ylmethoxy)pentyl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1368806-91-0
2-mercapto-N-[5-(5-methyl-3-phenylisoxazol-4-ylmethoxy)pentyl]propionamide

Guidance literature:: Multi-step reaction with 9 steps

1: N-chloro-succinimide; aluminum oxide / 40 °C / Microwave irradiation

2: triethylamine / tetrahydrofuran / 1 h / 70 °C / Microwave irradiation

3: water; sodium hydroxide / methanol / 4 h / 60 °C

4: borane-THF / tetrahydrofuran / 0 - 20 °C

5: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

6: sodium hydride / N,N-dimethyl-formamide / -20 - 20 °C

7: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

8: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

9: triethylsilane; trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With 1H-imidazole; triethylsilane; aluminum oxide; N-chloro-succinimide; borane-THF; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; iodine; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 5: Appel reaction;
DOI:10.1002/cmdc.201100522

Reference yield:

: 1368806-88-5
N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide

: 1368806-91-0
2-mercapto-N-[5-(5-methyl-3-phenylisoxazol-4-ylmethoxy)pentyl]propionamide

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1002/cmdc.201100522

Reference yield:

: C₁₆H₂₂N₂O₂

: 1368806-91-0
2-mercapto-N-[5-(5-methyl-3-phenylisoxazol-4-ylmethoxy)pentyl]propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

2: triethylsilane; trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With triethylsilane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/cmdc.201100522