(S)-1-{(2S,4S,6R)-6-[3-methoxy-4-(methoxymethoxy)-phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran-2-yl}-2-[4-(methoxymethoxy)phenyl]ethanol

Base Information

Chemical Name:(S)-1-{(2S,4S,6R)-6-[3-methoxy-4-(methoxymethoxy)-phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran-2-yl}-2-[4-(methoxymethoxy)phenyl]ethanol
CAS No.:1609536-99-3
Molecular Formula:C₂₆H₃₆O₉
Molecular Weight:492.566
Hs Code.:

Synonyms:(S)-1-{(2S,4S,6R)-6-[3-methoxy-4-(methoxymethoxy)-phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran-2-yl}-2-[4-(methoxymethoxy)phenyl]ethanol

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Chemical Property of (S)-1-{(2S,4S,6R)-6-[3-methoxy-4-(methoxymethoxy)-phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran-2-yl}-2-[4-(methoxymethoxy)phenyl]ethanol

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Technology Process of (S)-1-{(2S,4S,6R)-6-[3-methoxy-4-(methoxymethoxy)-phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran-2-yl}-2-[4-(methoxymethoxy)phenyl]ethanol

There total 10 articles about (S)-1-{(2S,4S,6R)-6-[3-methoxy-4-(methoxymethoxy)-phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran-2-yl}-2-[4-(methoxymethoxy)phenyl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₃₀O₉

: 1609536-99-3
(S)-1-{(2S,4S,6R)-6-[3-methoxy-4-(methoxymethoxy)-phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran-2-yl}-2-[4-(methoxymethoxy)phenyl]ethanol

Guidance literature:: With hydrogen; In ethanol;
DOI:10.1055/s-0033-1340181

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1609536-99-3
(S)-1-{(2S,4S,6R)-6-[3-methoxy-4-(methoxymethoxy)-phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran-2-yl}-2-[4-(methoxymethoxy)phenyl]ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 4 h / 0 - 20 °C

2: potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 6 h / 20 °C

4: methanesulfinamide; AD-mix-α / tert-butyl alcohol; water / 24 h / 0 °C

5: triethylamine / dichloromethane

6: hydrogen / ethanol

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; methanesulfinamide; AD-mix-α; potassium tert-butylate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; tert-butyl alcohol; 4: |Sharpless Dihydroxylation;
DOI:10.1055/s-0033-1340181

Reference yield:

: 6515-21-5
4-methoxymethoxy-benzaldehyde

: 1609536-99-3
(S)-1-{(2S,4S,6R)-6-[3-methoxy-4-(methoxymethoxy)-phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran-2-yl}-2-[4-(methoxymethoxy)phenyl]ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 6 h / 20 °C

3: methanesulfinamide; AD-mix-α / tert-butyl alcohol; water / 24 h / 0 °C

4: triethylamine / dichloromethane

5: hydrogen / ethanol

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methanesulfinamide; AD-mix-α; potassium tert-butylate; hydrogen; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; tert-butyl alcohol; 3: |Sharpless Dihydroxylation;
DOI:10.1055/s-0033-1340181