N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide

Base Information

Chemical Name:N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide
CAS No.:1040720-97-5
Molecular Formula:C₁₈H₂₃ClN₄O
Molecular Weight:346.86
Hs Code.:

Synonyms:N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide

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Chemical Property of N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide

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Technology Process of N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide

There total 7 articles about N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1040724-41-1
5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-ylamine

: C₁₁H₁₇N₃O

: 1040720-97-5
N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide

Guidance literature:: In 1,2-dichloro-ethane; at 50 ℃; for 10h;
DOI:10.1016/j.ejmech.2014.03.031

Reference yield:

: 7499-07-2
4-chloro-2-methylbenzoic acid

: 1040720-97-5
N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / Reflux

2: n-butyllithium / acetonitrile; toluene; hexane / 0.33 h / -78 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 18 h / Reflux

4: 1,2-dichloro-ethane / 10 h / 50 °C

With n-butyllithium; sulfuric acid; hydrazine hydrate; In ethanol; hexane; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1016/j.ejmech.2014.03.031

Reference yield:

: 1205055-78-2
3-(4-chloro-2-methylphenyl)-3-oxopropanenitrile

: 1040720-97-5
N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 18 h / Reflux

2: 1,2-dichloro-ethane / 10 h / 50 °C

With hydrazine hydrate; In ethanol; 1,2-dichloro-ethane;
DOI:10.1016/j.ejmech.2014.03.031