N⁵-(1-cyclopropylpiperidin-4-yl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine

Base Information

• Chemical Name: N⁵-(1-cyclopropylpiperidin-4-yl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine
• CAS No.: 1361570-30-0
• Molecular Formula: C₂₅H₂₇FN₈
• Molecular Weight: 458.541

Synonyms:N⁵-(1-cyclopropylpiperidin-4-yl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine

Chemical Property of N⁵-(1-cyclopropylpiperidin-4-yl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine

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Technology Process of N⁵-(1-cyclopropylpiperidin-4-yl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine

There total 1 articles about N⁵-(1-cyclopropylpiperidin-4-yl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-cyclopropylpiperidin-4-one (62813-01-8) + 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine (428854-21-1) → N5-(1-cyclopropylpiperidin-4-yl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine (1361570-30-0)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 48h;

Reference yield: 37.0%

bis(trichloromethyl) carbonate (32315-10-9) + N5-(1-cyclopropylpiperidin-4-yl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine (1361570-30-0) → 7-(1-cyclopropylpiperidin-4-yl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dihydro-8H-purin-8-one (1361569-79-0)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 0.5h;

upstream raw materials:

1-cyclopropylpiperidin-4-one

2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine

Downstream raw materials:

7-(1-cyclopropylpiperidin-4-yl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dihydro-8H-purin-8-one

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