1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine

Base Information

• Chemical Name: 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine
• CAS No.: 938055-76-6
• Molecular Formula: C₂₉H₂₉F₃N₆O₁₀S₂
• Molecular Weight: 742.711
• Mol file: 938055-76-6.mol

Synonyms:1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine

Chemical Property of 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine

There total 4 articles about 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine (938055-75-5) → 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine (938055-76-6)

Guidance literature:

N-benzoyladenine; With N,O-Bis(trimethylsilyl)acetamide; In DCE; for 1h; Heating / reflux;

1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine; With trimethylsilyl trifluoromethanesulfonate; In DCE; for 16h; Heating / reflux;

Reference yield: 57.0%

1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine (938055-75-5) + N-benzoyladenine (4005-49-6) → 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine (938055-76-6)

Guidance literature:

With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane;

DOI:10.1080/15257770600793729

Reference yield:

methanesulfonic acid 4-amino-3-benzyloxy-2-methanesulfonyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester → 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine (938055-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / BSA; TMSOTf / 1,2-dichloro-ethane

With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane;

DOI:10.1080/15257770600793729

upstream raw materials:

1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine

N-benzoyladenine

1-[2-azido-3-O-benzyl-2-deoxy-5-O-methanesulfonyl-4-C-(methanesulfonyloxymethyl)-β-D-erythro-pentofuranosyl]thymine

Downstream raw materials:

benzoic acid 3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2-oxa-5-aza-bicyclo[2.2.1]hept-1-ylmethyl ester

[3-(6-amino-purin-9-yl)-7-benzyloxy-2-oxa-5-aza-bicyclo[2.2.1]hept-1-yl]-methanol

(1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N₆-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane