1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine

Base Information

• Chemical Name: 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine
• CAS No.: 938055-75-5
• Molecular Formula: C₂₂H₂₆F₃N₃O₁₁S₂
• Molecular Weight: 629.589
• Mol file: 938055-75-5.mol

Synonyms:1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine

Chemical Property of 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine

There total 2 articles about 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonic acid 4-amino-3-benzyloxy-2-methanesulfonyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester + trifluoroacetic anhydride (407-25-0) → 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine (938055-75-5)

Guidance literature:

DOI:10.1080/15257770600793729

Reference yield:

1-[2-azido-3-O-benzyl-2-deoxy-5-O-methanesulfonyl-4-C-(methanesulfonyloxymethyl)-β-D-erythro-pentofuranosyl]thymine (552856-41-4) → 1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine (938055-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: PMe₃ / tetrahydrofuran

With trimethylphosphane; In tetrahydrofuran;

DOI:10.1080/15257770600793729

Reference yield: 58.0%

1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine (938055-75-5) + 2-Amino-6-chloropurin (10310-21-1) → methanesulfonic acid 5-(2-amino-6-chloro-purin-9-yl)-3-benzyloxy-2-methanesulfonyloxymethyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-furan-2-ylmethyl ester (938055-80-2)

Guidance literature:

With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane;

DOI:10.1080/15257770600793729

upstream raw materials:

trifluoroacetic anhydride

1-[2-azido-3-O-benzyl-2-deoxy-5-O-methanesulfonyl-4-C-(methanesulfonyloxymethyl)-β-D-erythro-pentofuranosyl]thymine

Downstream raw materials:

methanesulfonic acid 5-(2-amino-6-chloro-purin-9-yl)-3-benzyloxy-2-methanesulfonyloxymethyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-furan-2-ylmethyl ester

1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine

[3-(6-amino-purin-9-yl)-7-benzyloxy-2-oxa-5-aza-bicyclo[2.2.1]hept-1-yl]-methanol

methanesulfonic acid 3-(2-amino-6-chloro-purin-9-yl)-7-benzyloxy-2-oxa-5-aza-bicyclo[2.2.1]hept-1-ylmethyl ester