C₄₁H₄₇N₇O₅

Base Information

• Chemical Name: C₄₁H₄₇N₇O₅
• CAS No.: 1352393-34-0
• Molecular Formula: C₄₁H₄₇N₇O₅
• Molecular Weight: 717.868
• Mol file: 1352393-34-0.mol

Synonyms:C₄₁H₄₇N₇O₅

Chemical Property of C₄₁H₄₇N₇O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₄₇N₇O₅

There total 6 articles about C₄₁H₄₇N₇O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methyl-2,5-dihydro-1H-pyrrole-1-carboxylate (1352393-13-5) + C22H26N4O3 (1256385-01-9) → C41H47N7O5 (1352393-34-0)

Guidance literature:

With triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 110 ℃;

Reference yield:

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate (102195-80-2) → C41H47N7O5 (1352393-34-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

1.2: 3 h / -78 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / 95 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

3.2: pH 3

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

5.1: triethylamine; ammonium acetate / xylene / 2 h / 140 °C / sealed tube

6.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 110 °C

With lithium hydroxide monohydrate; ammonium acetate; water; sodium hexamethyldisilazane; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; xylene; 6.1: Sonogashira Coupling;

Reference yield:

(S)-4-trifluoromethanesulfonyloxy-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (462125-00-4) → C41H47N7O5 (1352393-34-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / 95 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

2.2: pH 3

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

4.1: triethylamine; ammonium acetate / xylene / 2 h / 140 °C / sealed tube

5.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 110 °C

With lithium hydroxide monohydrate; ammonium acetate; water; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; xylene; 5.1: Sonogashira Coupling;

upstream raw materials:

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

(S)-4-trifluoromethanesulfonyloxy-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester