3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl alcohol

Base Information

Chemical Name:3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl alcohol
CAS No.:852947-88-7
Molecular Formula:C₁₈H₁₉Cl₂NO₅S
Molecular Weight:432.325
Hs Code.:

Synonyms:3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl alcohol

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Chemical Property of 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl alcohol

Chemical Property:

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Technology Process of 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl alcohol

There total 4 articles about 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 852947-87-6
methyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzoate

: 852947-88-7
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl alcohol

Guidance literature:: methyl 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzoate; With diisobutylaluminium hydride; In dichloromethane; at -78 - 20 ℃; for 5h;

With water; sodium fluoride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 852947-86-5
methyl 3,5-dichloro-4-(4'-hydroxyphenoxy)benzoate

: 852947-88-7
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl alcohol

Guidance literature:: Multi-step reaction with 3 steps

1.1: chlorosulfonic acid / chloroform / 1 h / 0 °C

2.1: tetrahydrofuran / 16 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane / 5 h / -78 - 20 °C

3.2: 1 h / 0 - 20 °C

With chlorosulfonic acid; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; chloroform;

Reference yield:

: C₁₄H₁₀Cl₂O₇S

: 852947-88-7
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 16 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane / 5 h / -78 - 20 °C

2.2: 1 h / 0 - 20 °C

With diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;