3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl bromide

Base Information

Chemical Name:3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl bromide
CAS No.:852947-89-8
Molecular Formula:C₁₈H₁₈BrCl₂NO₄S
Molecular Weight:495.221
Hs Code.:

Synonyms:3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl bromide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl bromide

Chemical Property:

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Technology Process of 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl bromide

There total 4 articles about 3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 852947-88-7
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl alcohol

: 852947-89-8
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl bromide

Guidance literature:: With phosphorus tribromide; In 1,2-dimethoxyethane; diethyl ether; at 0 ℃; for 5h;

Reference yield:

: 852947-86-5
methyl 3,5-dichloro-4-(4'-hydroxyphenoxy)benzoate

: 852947-89-8
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl bromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: chlorosulfonic acid / chloroform / 1 h / 0 °C

2.1: tetrahydrofuran / 16 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane / 5 h / -78 - 20 °C

3.2: 1 h / 0 - 20 °C

4.1: phosphorus tribromide / 1,2-dimethoxyethane; diethyl ether / 5 h / 0 °C

With chlorosulfonic acid; phosphorus tribromide; diisobutylaluminium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; chloroform;

Reference yield:

: C₁₄H₁₀Cl₂O₇S

: 852947-89-8
3,5-dichloro-4-[4'-hydroxy-3'-(N-piperidinylsulfonamido)phenoxy]benzyl bromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 16 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane / 5 h / -78 - 20 °C

2.2: 1 h / 0 - 20 °C

3.1: phosphorus tribromide / 1,2-dimethoxyethane; diethyl ether / 5 h / 0 °C

With phosphorus tribromide; diisobutylaluminium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane;