(1S,2S)-2-[(Benzyloxycarbamoyl-methyl)-methyl-carbamoyl]-cyclohexanecarboxylic acid

Base Information

• Chemical Name: (1S,2S)-2-[(Benzyloxycarbamoyl-methyl)-methyl-carbamoyl]-cyclohexanecarboxylic acid
• CAS No.: 147201-74-9
• Molecular Formula: C₁₈H₂₄N₂O₅
• Molecular Weight: 348.399
• Mol file: 147201-74-9.mol

Synonyms:(1S,2S)-2-[(Benzyloxycarbamoyl-methyl)-methyl-carbamoyl]-cyclohexanecarboxylic acid

Chemical Property of (1S,2S)-2-[(Benzyloxycarbamoyl-methyl)-methyl-carbamoyl]-cyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-2-[(Benzyloxycarbamoyl-methyl)-methyl-carbamoyl]-cyclohexanecarboxylic acid

There total 3 articles about (1S,2S)-2-[(Benzyloxycarbamoyl-methyl)-methyl-carbamoyl]-cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S)-trans-1,2-cyclohexanedicarboxylic anhydride (31982-85-1) + 2-(methylamino)-N-(benzyloxy)acetamide hydrochloride → (1S,2S)-2-[(Benzyloxycarbamoyl-methyl)-methyl-carbamoyl]-cyclohexanecarboxylic acid (147201-74-9)

Guidance literature:

With triethylamine; In dichloromethane; at 5 ℃; for 2h;

DOI:10.1021/jm00058a006

Reference yield:

O-benzylhydoxylamine hydrochloride (2687-43-6) → (1S,2S)-2-[(Benzyloxycarbamoyl-methyl)-methyl-carbamoyl]-cyclohexanecarboxylic acid (147201-74-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / triethylamine, 1,3-dicyclohexylcarbodiimide / CHCl₃ / Ambient temperature

2: 78.5 percent / HCl gas / ethyl acetate / 2 h / 0 °C

3: triethylamine / CH₂Cl₂ / 2 h / 5 °C

With hydrogenchloride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; ethyl acetate;

DOI:10.1021/jm00058a006

Reference yield:

2-(BOC-methylamino)-N-(benzyloxy)acetamide (137022-79-8) → (1S,2S)-2-[(Benzyloxycarbamoyl-methyl)-methyl-carbamoyl]-cyclohexanecarboxylic acid (147201-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 78.5 percent / HCl gas / ethyl acetate / 2 h / 0 °C

2: triethylamine / CH₂Cl₂ / 2 h / 5 °C

With hydrogenchloride; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1021/jm00058a006

upstream raw materials:

(1S,2S)-trans-1,2-cyclohexanedicarboxylic anhydride

O-benzylhydoxylamine hydrochloride

2-(BOC-methylamino)-N-(benzyloxy)acetamide