N-(tert-butyloxycarbonyl)-D-leucyl-L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide

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Chemical Name:N-(tert-butyloxycarbonyl)-D-leucyl-L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide
CAS No.:1215172-80-7
Molecular Formula:C₃₂H₄₃N₅O₆
Molecular Weight:593.723
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-D-leucyl-L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide

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Chemical Property of N-(tert-butyloxycarbonyl)-D-leucyl-L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide

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Technology Process of N-(tert-butyloxycarbonyl)-D-leucyl-L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide

There total 8 articles about N-(tert-butyloxycarbonyl)-D-leucyl-L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 16937-99-8,53296-34-7
N-Boc-D-Leu

: L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide hydrochloride

: 1215172-80-7
N-(tert-butyloxycarbonyl)-D-leucyl-L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere; Cooling with ice;

Reference yield: 69.0%

: 16937-99-8,53296-34-7
N-Boc-D-Leu

: C₂₁H₂₄N₄O₃*(x)ClH

: 1215172-80-7
N-(tert-butyloxycarbonyl)-D-leucyl-L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 5.33333h; Inert atmosphere;

Reference yield: 11.0%

: 63202-94-8
(S)-1-((R)-2-(tert-butoxycarbonylamino)-4-methylpentanoyl)pyrrolidine-2-carboxylic acid

: N'-benzyloxycarbonyl-4-aminomethylbenzamidine hydrochloride

: 1215172-80-7
C₃₂H₄₃N₅O₆

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm9016416